2026-06-08T22:08:25Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1088702025-03-18T14:38:03Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Martínez Negro, María author González-Rubio, G author Aicart Sospedra, Emilio author Landfester, K author Guerrero Martínez, Andrés author Junquera González, María Elena author 2021 Colloidal nanoparticles (NPs) have attracted significant attention due to their unique physicochemical properties suitable for diagnosing and treating different human diseases. Nevertheless, the successful implementation of NPs in medicine demands a proper understanding of their interactions with the different proteins found in biological fluids. Once introduced into the body, NPs are covered by a protein corona (PC) that determines the biological behavior of the NPs. The formation of the PC can eventually favor the rapid clearance of the NPs from the body before fulfilling the desired objective or lead to increased cytotoxicity. The PC nature varies as a function of the different repulsive and attractive forces that govern the NP-protein interaction and their colloidal stability. This review focuses on the phenomenon of PC formation on NPs from a physicochemical perspective, aiming to provide a general overview of this critical process. Main issues related to NP toxicity and clearance from the body as a result of protein adsorption are covered, including the most promising strategies to control PC formation and, thereby, ensure the successful application of NPs in nanomedicine. Martínez-Negro M, González-Rubio G, Aicart E, Landfester K, Guerrero-Martínez A, Junquera E. Insights into colloidal nanoparticle-protein corona interactions for nanomedicine applications. Advances in Colloid and Interface Science 2021;289:102366. https://doi.org/10.1016/j.cis.2021.102366. 0001-8686 10.1016/j.cis.2021.102366 https://hdl.handle.net/20.500.14352/108870 https://doi.org/10.1016/j.cis.2021.102366 https://linkinghub.elsevier.com/retrieve/pii/S0001868621000075 Insights into colloidal nanoparticle-protein corona interactions for nanomedicine applications