2026-06-28T20:33:18Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1090162025-03-18T13:54:14Zcom_20.500.14352_14col_20.500.14352_15
Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats
Álvarez Cilleros, David
López-Oliva Muñoz, María Elvira
Morales Cano, Daniel
Barreira Barba, Bianca
Pérez Vizcaíno, Francisco
Goya, Luis
Ramos, Sonia
Martín, María Ángeles
Scope
The aim of the present study is to investigate the potential protective effect of a cocoa‐rich diet on functional and structural vascular alterations in diabetes and the mechanism involved.
Methods and results
Male Zucker diabetic fatty (ZDF) rats are fed on a standard (ZDF‐C) or cocoa‐rich diet (ZDF‐Co) from week 10 to 20 of life. Diabetic ZDF‐C rats showed increased blood pressure and enhanced aortic stiffness, as demonstrated by the increased pulse pressure and the augmented aortic medial thickness with loss and disruption of elastic fibres. Interestingly, cocoa intake strongly avoided all these adverse effects and reduced aortic oxidative stress. Mechanistically, cocoa diet prevented sirtuin‐1 (SIRT‐1) depletion and increased NADPH oxidases (NOXs) and reactive oxygen species production as well as reduced active nuclear factor E2 related factor 2 (Nrf2) and their antioxidant products.
Conclusion
The results demonstrate for the first time that a cocoa‐rich diet strongly prevents aortic stiffening and remodeling in diabetic animals and avoids aortic oxidative stress. It is suggested that this effect could be mediated via its effects on SIRT‐1, NOXs, and Nrf2.
2024-10-16T12:16:32Z
2024-10-16T12:16:32Z
2024-10-16T12:16:32Z
2019-06-12
journal article
https://hdl.handle.net/20.500.14352/109016
1613-4125
10.1002/mnfr.201900044
1613-4133
eng
info:eu-repo/grantAgreement/MINECO//AGL 2015–67087-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013 -2016/SAF2016-77222-R
Álvarez-Cilleros D, López-Oliva ME, Morales-Cano D, Barreira B, Pérez-Vizcaíno F, Goya L, Ramos S, Martín MÁ. Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats. Mol Nutr Food Res. 2019 Sep;63(18):e1900044. doi: 10.1002/mnfr.201900044. Epub 2019 Jun 12. PMID: 31144780.
restricted access
Wiley