2026-06-28T20:28:11Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1090312025-03-18T13:05:53Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Domínguez Valdés, Teresa author Bonnin Arias, Cristina Natalia author Álvarez Peregrina, Cristina author González Gálvez, Beatriz author Sánchez Tena, Miguel Ángel author Germain, Francisco author De la Villa, Pedro author Sánchez Ramos, Celia author 2024-08 Background: Rooms illuminated by “black light” (<400 nm wavelength) has become popular, but there is not enough scientific evidence to support its implementation. This study aims to assess the effects of violet light (392 nm) on the circadian rest–activity rhythm and the visual system through animal experimentation. Materials and results: Five groups of four mice were exposed to different white light, violet light, and dark periods, and their circadian rhythm was analyzed by measuring the circadian period using rest–activity cycles. Electroretinographic recordings and structural analysis of the retina were also performed on experimental animals. Results: Our study demonstrates that mice present normal circadian activity during exposure to violet light, taking rest not only under white light but under violet lighting periods. However, mice suffered a decrease in electrical retinal response after exposure to violet light as measured by electroretinography. Nevertheless, no structural changes were observed in the retinas of the animals under different lighting conditions. Conclusions: Violet light elicits circadian rest–activity rhythm in mice but alters their visual function, although no structural changes are observed after short periods of violet light exposure. Domínguez-Valdés, T.; Bonnin-Arias, C.; Alvarez-Peregrina, C.; Galvez, B.G.; Sanchez-Tena, M.A.; Germain, F.; de la Villa, P.; Sánchez-Ramos, C. Violet Light Effects on the Circadian Rest–Activity Rhythm and the Visual System. Clocks & Sleep 2024, 6, 433-445. https://doi.org/10.3390/clockssleep6030029 10.3390/clockssleep6030029 https://hdl.handle.net/20.500.14352/109031 https://doi.org/10.3390/clockssleep6030029 https://www.mdpi.com/2624-5175/6/3/29 Violet Light Effects on the Circadian Rest–Activity Rhythm and the Visual System