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00925njm 22002777a 4500 dc Welsh, Donald G. author Tran, Cam Ha T. author Hald, Bjorn O. author Sancho González, María author 2018-01-06 Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli, sparsely generated in tissue, eliciting electrical responses that conduct lengthwise among electrically coupled vascular cells. The conducted response is the focus of this topical review, and in this regard, the authors highlight literature that advances an appreciation of functional significance, cellular mechanisms, and biophysical principles. Of particular note, this review stresses that conduction is enabled by a defined pattern of charge movement along the arterial wall as set by three key parameters (tissue structure, gap junctional resistivity, and ion channel activity). The impact of disease on conduction is carefully discussed, as are potential strategies to restore this key biological response and, along with it, the match of blood flow delivery with tissue energetic demand. Welsh DG, Tran CHT, Hald BO, Sancho M. The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control. Annu Rev Pharmacol Toxicol. 58:391-410. doi: 10.1146/annurev-pharmtox-010617-052623. 0362-1642 10.1146/annurev-pharmtox-010617-052623 https://hdl.handle.net/20.500.14352/109660 1545-4304 https://doi.org/10.1146/annurev-pharmtox-010617-052623 https://www.annualreviews.org/content/journals/10.1146/annurev-pharmtox-010617-052623 The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control