2026-06-28T20:24:57Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1100492024-11-07T01:13:00Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Jin, Zhe-Wu author Yamada, Tomonori author Kim, Ji Hyun author Rodríguez Vázquez, José Francisco author Murakami, Gen author Arakawa, Keiji 2024-11-06T08:35:44Z 2024-11-06T08:35:44Z 2015-10-05 Jin ZW, Yamada T, Kim JH, Rodríguez-Vázquez JF, Murakami G, Arakawa K. Pathogenesis of solitary right aortic arch: a mass effect hypothesis based on observations of serial human embryonic sections. Cardiology in the Young. 2017;27(2):359-368. doi:10.1017/S1047951115002152 1047-9511 10.1017/s1047951115002152 https://hdl.handle.net/20.500.14352/110049 1467-1107 https://doi.org/10.1017/S1047951115002152 https://www.cambridge.org/core/journals/cardiology-in-the-young/article/pathogenesis-of-solitary-right-aortic-arch-a-mass-effect-hypothesis-based-on-observations-of-serial-human-embryonic-sections/4693AC4D2B20D127328924EB33A9162A In general, solitary right aortic arch carries the left-sided ductus arteriosus communicating between the left subclavian and pulmonary arteries or the right-sided ductus connecting the descending aorta to the left pulmonary artery. Serial sections of fifteen 5- to 6-week-old embryos and ten 8- to 9-week-old fetuses suggested that the pathogenesis was unrelated to inversion due to dysfunction in gene cascades that control the systemic left/right axis. With inversion, conversely, the ductus or the sixth pharyngeal arch artery should connect to the right pulmonary artery. The disappearance of the right aortic arch started before the caudal migration of the aortic attachment of the ductus. Sympathetic nerve ganglia developed immediately posterior to both aortae, with a single embryonic specimen showing a large ganglion at the midline close to the union of the aortic arches. These ganglia may interfere with blood flow through the distal left arch, resulting in the ductus ending at the descending aorta behind the oesophagus. In another fetus examined, a midline shift of the ductus course resulted in the trachea curving posteriorly. Therefore, solitary right arch is likely to accompany abnormalities of the surrounding structures. The timing and site of the obstruction should be different between types: an almost midline obstruction near the aortic union needed for the development of the left-sided ductus and a distal obstruction near the left subclavian arterial origin needed for the development of the right-sided ductus. A mass effect of the sympathetic ganglia may explain the pathogenesis of any type of anomalous ductus arteriosus shown in previous reports of the solitary right arch. eng Pathogenesis of solitary right aortic arch: a mass effect hypothesis based on observations of serial human embryonic sections journal article 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URL https://docta.ucm.es/bitstreams/a5ffb998-9893-4de5-9a82-7e7e9ad9eaae/download File MD5 0015e3a844ac45e9df58783c7e9b34d8 2515996 application/pdf pathogenesis.pdf