2026-06-08T01:05:57Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1104582024-11-13T00:55:55Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
advisor
author
Caballero Marcos, Aránzazu
author
Catalán Alonso, Pilar
author
López Baena, José Ángel
author
Bañares Cañizares, Rafael
author
Salcedo Plaza, María Magdalena
editor
2024-11-12T12:19:44Z
2024-11-12T12:19:44Z
2021-11
Caballero-Marcos A, Romero-Cristóbal M, Puerto M, Fernández-Yunquera A, Dieguez L, Navarrete C, Clemente A, Diaz-Fontenla F, Catalán P, Rincón D, López-Baena JÁ, Bañares Cañizares R, Salcedo M. HCV eradication in recurrent hepatitis C after liver transplantation normalizes enhanced endothelial activation. Transpl Int. 2021 Nov;34(11):2214-2225. doi: 10.1111/tri.14000. Epub 2021 Sep 14. PMID: 34346111.
https://hdl.handle.net/20.500.14352/110458
https://doi.org/10.1111/tri.14000
34346111
https://onlinelibrary.wiley.com/doi/10.1111/tri.14000
The increased risk of cardiovascular disease (CVD) conferred by hepatitis C virus (HCV) is especially relevant after liver transplantation (LT), but its mechanism is still not well defined. This study aimed to evaluate the influence of HCV eradication in inflammatory and endothelial activation markers after LT. We evaluated inflammatory (TNF-alfa, IL-6, IL-8, and MCP-1) and endothelial activation (E-selectin, ICAM-1, VCAM-1, and MMP-9) markers before and after eradication in 45 LT recipients with HCV infection (LT+/HCV+) and 44 non-transplanted HCV-infected patients (LT-/HCV+). We also considered an additional group of 40 LT recipients without HCV infection (LT+/HCV-). LT+/HCV+ patients presented a higher endothelial activation status before eradication compared with LT+/HCV- patients. However, levels of E-selectin, ICAM-1, VCAM-1, and MMP-9 were comparable between LT+/HCV+ and LT-/HCV+ patients before eradication. HCV eradication decreased ICAM-1 (5466.55 pg/ml vs. 3354.88 pg/ml, P < 0.001) and VCAM-1 (10456.52 pg/ml vs. 6658.85 pg/ml, P < 0.001) levels in LT+/HCV+ and LT-/HCV+ patients. Remarkably, HCV eradication restored levels of endothelial activation markers of LT+/HCV+ patients compared with that of LT+/HCV- patients. HCV plays a major role in endothelial dysfunction after LT. Furthermore, HCV eradication restores endothelial activation despite the exposure to immunosuppressive therapy.
eng
HCV eradication in recurrent hepatitis C after liver transplantation normalizes enhanced endothelial activation
journal article
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URL
https://docta.ucm.es/bitstreams/6c7426b8-574d-4c0b-9b46-e0fdd53c073a/download
File
MD5
92f5d9eccf1b9354214dc2c2bf179ba5
1102110
application/pdf
Caballero-Marcos et al. (2021) HCV eradication normalizes endothelial activation. Transpl Int.pdf