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oai:docta.ucm.es:20.500.14352/1118802025-03-18T11:50:20Zcom_20.500.14352_14col_20.500.14352_15

Regenerative medicine: Hydrogels and mesoporous silica nanoparticles Pablos Lagartos, Jesús Luis Lozano Borregón, Daniel Manzano García, Miguel Vallet Regí, María Dulce Nombre Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility and biodegradability, closely resemble living tissues. The versatility of hydrogels has fuelled their application in various fields, such as agriculture, biomaterials, the food industry, drug delivery, tissue engineering, and regenerative medicine. Their combination with nanoparticles, specifically with Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to the next level, since MSNs could improve the hydrogel mechanical properties, their ability to encapsulate and controlled release great amounts of different therapeutic agents, and their responsiveness to a variety of external and internal stimuli. In this review, the main features of both MSNs and hydrogels are introduced, followed by the discussion of different hydrogels-MSNs structures and an overview of their use in different applications, such as drug delivery technologies and tissue engineering. 2024-12-02T15:36:33Z 2024-12-02T15:36:33Z 2024-12-21 journal article Jesús L. Pablos, Daniel Lozano, Miguel Manzano, María Vallet-Regí, Regenerative medicine: Hydrogels and mesoporous silica nanoparticles, Materials Today Bio, Volume 29, 2024, 101342, https://doi.org/10.1016/j.mtbio.2024.101342. 2590-0064 10.1016/j.mtbio.2024.101342 https://hdl.handle.net/20.500.14352/111880 https://doi.org/10.1016/j.mtbio.2024.101342 eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106436RB-I00/ES/NANOPARTICULAS INTELIGENTES PARA EL HUESO OSTEOPOROTICO/ info:eu-repo/grantAgreement/EC/H2020/694160/EU http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier