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oai:docta.ucm.es:20.500.14352/1119292025-03-18T15:43:32Zcom_20.500.14352_14col_20.500.14352_15

Systemic regulatory T cells and IL-6 as prognostic factors for anatomical improvement of uveitic macular edema Matas, Jessica Díaz Valle, David Molins, Blanca Purpose: To investigate whether systemic immune mediators and circulating regulatory T cells (Tregs) could be prognostic factors for anatomic outcomes in macular edema secondary to non-infectious uveitis (UME). Methods: Multicenter, prospective, observational, 12-month follow-up study of 60 patients with UME. Macular edema was defined as central subfield thickness (CST) > 300 μm measured with spectral domain optical coherence tomography (SD-OCT). Serum samples and peripheral blood mononuclear cells (PBMC) were obtained from venous blood extraction at baseline. Serum levels of IL-1β, IL-6, IL-8, IL-17, MCP-1, TNF-α, IL-10, and VEGF were determined by Luminex. Tregs population, defined as CD3+CD4+FoxP3+ in PBMC, was determined by flow cytometry. Main outcome measure was the predictive association between searched mediators and CST sustained improvement, defined as CST < 300 microns or a 20% CST decrease, at 6 months maintained until 12-months compared to baseline levels. Results: Multivariate logistic regression analysis showed an association between CST sustained improvement at 12 months follow-up and IL-6 and Tregs baseline levels. Higher IL-6 levels were associated with less events of UME improvement (OR: 0.67, 95% CI (0.45–1.00), P = 0.042), whereas higher levels of Tregs favored such improvement (OR: 1.25, 95% CI: 1.12–2.56, P = 0.049). Conclusions: Increased levels of Tregs and reduced levels of IL-6 in serum may be prognostic factors of sustained anatomical improvement in UME. These findings could enforce the opportunity to develop more efficient and personalized therapeutic approaches to improve long-term visual prognosis in patients with UME. 2024-12-03T09:04:12Z 2024-12-03T09:04:12Z 2020-09-15 journal article Matas J, Llorenç V, Fonollosa A, Díaz-Valle D, Esquinas C, de la Maza MTS, Figueras-Roca M, Artaraz J, Berasategui B, Mesquida M, Adán A and Molins B (2020) Systemic Regulatory T Cells and IL-6 as Prognostic Factors for Anatomical Improvement of Uveitic Macular Edema. Front. Immunol. 11:579005. doi: 10.3389/fimmu.2020.579005 10.3389/fimmu.2020.579005 https://hdl.handle.net/20.500.14352/111929 1664-3224 https://doi.org/10.3389/fimmu.2020.579005 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.579005/full eng PI13/00217 PI13/00217 RD16/0008 http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Frontiers Media