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Small-molecule theranostics in Alzheimer's disease Sarabia Vallejo, Álvaro López-Alvarado Gutiérrez, María Pilar Menéndez Ramos, José Carlos 615:54 615.31 Alzheimer's disease Theranostic agents β-amyloid protein PET imaging Optical imaging Fluorescent probes Química farmaceútica 2390 Química Farmacéutica 2023 Acuerdos transformativos CRUE Alzheimer's Disease (AD) remains one of the most challenging health-related issues for our society. It is becoming increasingly prevalent, especially in developed countries, due to the rising life expectancy and, moreover, represents a considerable economic burden worldwide. All efforts at the discovery of new diagnostic and therapeutic tools in the last decades have invariably met with failure, making AD an incurable illness and underscoring the need for new approaches. In recent years, theranostic agents have emerged as an interesting strategy. They are molecules able to simultaneously provide diagnostic information and deliver therapeutic activity, allowing for the assessment of the molecule activity, the organism response and the pharmacokinetics. This makes these compounds promising for streamlining research on AD drugs and for their application in personalized medicine. We review here the field of small-molecule theranostic agents as promising tools for the development of novel diagnostic and therapeutic resources against AD, highlighting the positive and significant impact that theranostics can be expected to have in the near future in clinical practice. Ministerio de Ciencia e Innovación (España) Depto. de Química en Ciencias Farmacéuticas Fac. de Farmacia TRUE pub APC financiada por la UCM 2024-12-04T13:02:22Z 2024-12-04T13:02:22Z 2023-07-05 journal article VoR https://hdl.handle.net/20.500.14352/112062 0223-5234 10.1016/j.ejmech.2023.115382 eng PID2021-124983OB-I00 Álvaro Sarabia-Vallejo, Pilar López-Alvarado, J. Carlos Menéndez, Small-molecule theranostics in Alzheimer's disease, European Journal of Medicinal Chemistry, Volume 255, 2023, 115382, https://doi.org/10.1016/j.ejmech.2023.115382. Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf Elsevier