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oai:docta.ucm.es:20.500.14352/1121522025-03-18T12:10:50Zcom_20.500.14352_14col_20.500.14352_15

Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients Araos, Pedro Vidal Casado, Rebeca O'Shea Gaya, María Esther Rodríguez De Fonseca, Fernando Antonio Colado Megías, María Isabel 615.214 Ciencias Biomédicas Psicofarmacología 6113 Psicofarmacología Fondos FEDER The lack of effective treatments and a high rate of relapse in cocaine addiction constitute a major health problem. The present study was conducted to examine the expression of tryptophan-derived metabolites in the context of cocaine addiction and psychiatric comorbidity, which is common in addicted subjects. Abstinent patients with cocaine use disorder (CUD) and control subjects were recruited for a cross-sectional study. Participants were assessed with a semi-structured diagnostic interview (PRISM) based on DSM-IV-TR for substance and mental disorders. Plasma concentrations of tryptophan metabolites and their association with relevant CUD-related variables and psychiatric comorbidity were explored. We observed decreased plasma kynurenic acid concentrations in the cocaine group, however no associations between CUD-related variables and tryptophan-derived metabolites were found. In contrast, 5-HT concentrations were increased in CUD-patients and the diagnosis of different psychiatric disorders in the cocaine group was related to higher plasma 5-HT concentrations compared with non-comorbid patients. Therefore, while changes in plasma kynurenic acid concentrations appear to be directly associated with lifetime CUD, changes in 5-HT concentrations are associated with psychiatric comorbidity. These results emphasize the need to find potential biomarkers for a better stratification of cocaine-addicted patients in order to develop therapeutic approaches to prevent cocaine relapse. Instituto de Salud Carlos III (España) Ministerio de Economía y Competitividad (España) Ministerio de Sanidad, Servicios Sociales e Igualdad (España) Junta de Andalucía European Commission Depto. de Farmacología y Toxicología Fac. de Medicina TRUE pub 2024-12-05T12:47:33Z 2024-12-05T12:47:33Z 2019-11-14 journal article VoR https://hdl.handle.net/20.500.14352/112152 2045-2322 10.1038/s41598-019-53312-0 eng info:eu-repo/grantAgreement/MINECO//RD16/0017/0001 info:eu-repo/grantAgreement/MINECO//RD16/0017/0021 info:eu-repo/grantAgreement/MINECO//PI16%2F01698/ES/Lípidos transmisores derivados del ácido oleico: Estudio traslacional de su papel en los trastornos por uso de alcohol/ info:eu-repo/grantAgreement/MINECO//PI16%2F01953/ES/Estudio Traslacional del Sistema de Señalización de Quimioquina CX3CL1%2FR1 en la Adicción a Alcohol: Papel como Biomarcador Neuroinflamatorio/ info:eu-repo/grantAgreement/MSSSI/Plan Nacional sobre Drogas/049/2013 info:eu-repo/grantAgreement/MSSSI/Plan Nacional sobre Drogas/2017I017 Araos P, Vidal R, O'Shea E, Pedraz M, García-Marchena N, Serrano A, Suárez J, Castilla-Ortega E, Ruiz JJ, Campos-Cloute R, Santín LJ, Rodríguez de Fonseca F, Pavón FJ, Colado MI. Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients. Sci Rep. 2019 Nov 14;9(1):16842. doi: 10.1038/s41598-019-53312-0. PMID: 31727978; PMCID: PMC6856167. open access application/pdf Nature