2026-07-30T02:45:34Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1124722025-03-18T12:15:32Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Garrido Novelle, Marta author Naranjo Martínez, Beatriz author López Cánovas, Juan Luis author Díaz Ruíz, Alberto author 2025-01 The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly. Novelle, M. G., Naranjo-Martínez, B., López-Cánovas, J. L., & Díaz-Ruiz, A. (2025). Fecal microbiota transplantation, a tool to transfer healthy longevity. Ageing Research Reviews, 103, 102585. https://doi.org/10.1016/j.arr.2024.102585 1568-1637 10.1016/j.arr.2024.102585 https://hdl.handle.net/20.500.14352/112472 1872-9649 https://doi.org/10.1016/j.arr.2024.102585 Fecal microbiota transplantation, a tool to transfer healthy longevity