2026-07-29T01:53:45Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1124722025-03-18T12:15:32Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Garrido Novelle, Marta author Naranjo Martínez, Beatriz author López Cánovas, Juan Luis author Díaz Ruíz, Alberto 2024-12-11T17:00:20Z 2024-12-11T17:00:20Z 2025-01 Novelle, M. G., Naranjo-Martínez, B., López-Cánovas, J. L., & Díaz-Ruiz, A. (2025). Fecal microbiota transplantation, a tool to transfer healthy longevity. Ageing Research Reviews, 103, 102585. https://doi.org/10.1016/j.arr.2024.102585 1568-1637 10.1016/j.arr.2024.102585 https://hdl.handle.net/20.500.14352/112472 1872-9649 https://doi.org/10.1016/j.arr.2024.102585 The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly. eng Attribution 4.0 International Fecal microbiota transplantation, a tool to transfer healthy longevity journal article 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URL https://docta.ucm.es/bitstreams/fcf22590-6ce0-4b7f-9026-1f61c6bc511a/download File MD5 637847d243690bf44eecc2be531fc6fc 7475325 application/pdf Novelle MG et al., 2025.pdf URL https://docta.ucm.es/bitstreams/0fa1316d-4eaa-4d36-84a2-f9292e17c758/download File MD5 948d265d862832eba6f3948ffce65e17 173329 text/plain Novelle MG et al., 2025.pdf.txt