2026-07-31T10:59:34Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1124722025-03-18T12:15:32Zcom_20.500.14352_14col_20.500.14352_15

Fecal microbiota transplantation, a tool to transfer healthy longevity Garrido Novelle, Marta Naranjo Martínez, Beatriz López Cánovas, Juan Luis Díaz Ruíz, Alberto The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly. 2024-12-11T17:00:20Z 2024-12-11T17:00:20Z 2024-12-11T17:00:20Z 2025-01 journal article https://hdl.handle.net/20.500.14352/112472 1568-1637 10.1016/j.arr.2024.102585 1872-9649 eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106893RA-I00/ES/DESDE LA BIOLOGIA DEL ENVEJECIMIENTO HASTA INTERVENCIONES SOSTENIBLES: UNA APROXIMACION BASADA EN EL MICROBIOMA/ Novelle, M. G., Naranjo-Martínez, B., López-Cánovas, J. L., & Díaz-Ruiz, A. (2025). Fecal microbiota transplantation, a tool to transfer healthy longevity. Ageing Research Reviews, 103, 102585. https://doi.org/10.1016/j.arr.2024.102585 http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Elsevier