2026-07-30T02:45:10Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1124722025-03-18T12:15:32Zcom_20.500.14352_14col_20.500.14352_15

Fecal microbiota transplantation, a tool to transfer healthy longevity Garrido Novelle, Marta Naranjo Martínez, Beatriz López Cánovas, Juan Luis Díaz Ruíz, Alberto This work was supported by the following grants: i) RETOS Projects Program PID2019-106893RA-I00 (grant to A.D.R), funded by MICIU/AEI/10.13039/501100011033; ii) Ramon y Cajal Award RYC2021-033751-I (grant to A.D.R), funded by MICIU/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR; iii) CIVP21A7025 (grant to A.D.R), funded by Ramón Areces Foundation; iv) Talento Grant (2018-T1/BMD-11966; grant to A.D.R), funded by Comunidad de Madrid; and v) CIBERobn, an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain, which is supported by FEDER funds. Figure 1 was designed by Freepik. Some Icons on Figures 2-4 were modified from BioRender.com. The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly. 2024-12-11T17:00:20Z 2024-12-11T17:00:20Z 2025-01 journal article Novelle, M. G., Naranjo-Martínez, B., López-Cánovas, J. L., & Díaz-Ruiz, A. (2025). Fecal microbiota transplantation, a tool to transfer healthy longevity. Ageing Research Reviews, 103, 102585. https://doi.org/10.1016/j.arr.2024.102585 1568-1637 10.1016/j.arr.2024.102585 https://hdl.handle.net/20.500.14352/112472 1872-9649 https://doi.org/10.1016/j.arr.2024.102585 eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106893RA-I00/ES/DESDE LA BIOLOGIA DEL ENVEJECIMIENTO HASTA INTERVENCIONES SOSTENIBLES: UNA APROXIMACION BASADA EN EL MICROBIOMA/ http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Elsevier