2026-06-28T10:09:12Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1126912024-12-17T00:56:27Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Fernández Marcelo, Tamara author Morán, Alberto author Juan Chocano, María Del Carmen De author Pascua, Irene author Head, Jacqueline author Gómez, Ana author Hernando Trancho, Florentino author López-Asenjo, José A. author Hernández, Susana author Sánchez Pernaute, Andrés author Torres García, Antonio José author Benito De Las Heras, Manuel R. author Iniesta Serrano, María Pilar 2024-12-16T16:26:36Z 2024-12-16T16:26:36Z 2012-03-15 Fernández-Marcelo T, Morán A, de Juan C, Pascua I, Head J, Gómez A, Hernando F, López-Asenjo JA, Hernández S, Sánchez-Pernaute A, Torres AJ, Benito M, Iniesta P. Differential expression of senescence and cell death factors in non-small cell lung and colorectal tumors showing telomere attrition. Oncology. 2012;82(3):153-64. doi: 10.1159/000335678. Epub 2012 Mar 15. PMID: 22433385. 1423-02320030-2414 10.1159/000335678 https://hdl.handle.net/20.500.14352/112691 https://doi.org/10.1159/000335678 Objective: The main aim of this work is to investigate the expression of factors related to senescence and cell death pathways in non-small cell lung cancers (NSCLCs) and colorectal cancers (CRCs) in relation to telomere status. Methods: We analyzed 158 tissue samples, 36 NSCLCs, 43 CRCs, and their corresponding control tissues obtained from patients submitted to surgery. Telomere function was evaluated by determining telomerase activity and telomere length. Expression of factors related to senescence, cell death pathways, transformation and tumorigenesis was investigated using arrays. Results were validated by real-time quantitative PCR. Results: Considering tumors with telomere shortening, expression for BNIP3, DAPK1, NDRG1, EGFR, and CDKN2A was significantly higher in NSCLC than in CRC, whereas TP53 was overexpressed in CRC with respect to NSCLC. Moreover, compared to nontumor samples, DAPK1, GADD45A, SHC1, and TP53 were downregulated in the group of NSCLCs with telomere shortening, and no significant differences were found in CRC. Conclusions: In NSCLC, the failure of pathways which involve factors such as DAPK1, GADD45A, SHC1, and TP53, in response to short telomeres, could promote tumor progression. In CRC, the viability of these pathways in response to short telomeres could contribute to limiting tumorigenesis. eng Attribution-NonCommercial-NoDerivatives 4.0 International Differential Expression of Senescence and Cell Death Factors in Non-Small Cell Lung and Colorectal Tumors Showing Telomere Attrition journal article 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URL https://docta.ucm.es/bitstreams/fc3a7e05-eecd-451e-9336-03db6af09f2e/download File MD5 065d66c549ad19aed6fc6b74f49c56c9 993178 application/pdf 000335678.pdf