2026-06-27T23:50:38Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1130142024-12-20T00:49:48Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Froudist Walsh, Sean author Karolis, Vyacheslav author Caldinelli, Chiara author Brittain, Philip J. author Kroll, Jasmin author Rodríguez Toscano, Elisa author Tesse, Marcelo author Colquhoun, Matthew author Howes, Oliver author Dell' Acqua, Flavio author Thiebaut de Schotten, Michel author Murray, Robin M. author Williams, Steven C.R. author Nosarti, Chiara 2024-12-19T09:54:41Z 2024-12-19T09:54:41Z 2015 Froudist Walsh S., Karolis V., Caldinelli C., Brittain P.J., Kroll J., Rodríguez Toscano E., Tesse M., Colquhoun M., Howes O., Dell'Acqua F., Thiebaut de Schotten M., Murray R.M., Williams S.C. & Nosarti C.(2015). Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study. The Journal of Neuroscience, 35(48):15787-15799 99. 1529-24010270-6474 10.1523/JNEUROSCI.4769-14.2015 https://hdl.handle.net/20.500.14352/113014 http://dx.doi.org/10.1523/JNEUROSCI.4769-14.2015 26631462 https://www.jneurosci.org/content/35/48/15787 The human brain can adapt to overcome injury even years after an initial insult. One hypothesis states that early brain injury survivors, by taking advantage of critical periods of high plasticity during childhood, should recover more successfully than those who suffer injury later in life. This hypothesis has been challenged by recent studies showing worse cognitive outcome in individuals with early brain injury, compared with individuals with later brain injury, with working memory particularly affected. We invited individuals who suffered perinatal brain injury (PBI) for an fMRI/diffusion MRI tractography study of working memory and hypothesized that, 30 years after the initial injury, working memory deficits in the PBI group would remain, despite compensatory activation in areas outside the typical working memory network. Furthermore we hypothesized that the amount of functional reorganization would be related to the level of injury to the dorsal cingulum tract, which connects medial frontal and parietal working memory structures. We found that adults who suffered PBI did not significantly differ from controls in working memory performance. They exhibited less activation in classic frontoparietal working memory areas and a relative overactivation of bilateral perisylvian cortex compared with controls. Structurally, the dorsal cingulum volume and hindrance-modulated orientational anisotropy was significantly reduced in the PBI group. Furthermore there was uniquely in the PBI group a significant negative correlation between the volume of this tract and activation in the bilateral perisylvian cortex and a positive correlation between this activation and task performance. This provides the first evidence of compensatory plasticity of the working memory network following PBI. eng Attribution 4.0 International Very early brain damage leads to remodeling of the working memory system in adulthood: A combined fMRI/ Tractography study journal article 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URL https://docta.ucm.es/bitstreams/f54de998-4731-4fb3-8ba7-30736a4273ce/download File MD5 100a54ea6c0e47d0f5bb08f4992f14d3 2183835 application/pdf 2015_Froudist_Very Early Brain Damage Leads to Remodeling of the.pdf