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oai:docta.ucm.es:20.500.14352/1132252025-03-18T11:53:50Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc López-Pintor Muñoz, Rosa María author González Serrano, José author Vallina, Carmen author Ivaylova Serkedzhieva, Katerina author Virto Ruiz, Leire author Nuevo, Paula author Caponio, Vito Carlo Alberto author Iniesta Albentosa, Margarita Isabel author Rodríguez Santamarta, Tania author Lequerica Fernández, Paloma author Iglesias Velázquez, Óscar author Hernández Vallejo, Gonzalo author de Vicente, Juan Carlos author 2025-01-07 Introduction: Salivary Lactate Dehydrogenase (sLDH) levels seem to be higher in patients with Oral Squamous Cell Carcinoma (OSCC) and Oral Potentially Malignant Disorders (OPMD) than a control group (CG). Methods: Case-control study. Patients with OPMD [oral leukoplakia (OL) and oral lichen planus (OLP)] and OSCC who attended two services in Spain were selected. sLDH in saliva was measured. Epidemiological, periodontal and specific variables related to OPMD and OSCC were collected. Results: A total of 92 patients were included: 12 with OSCC, 51 with OPMD (17 OL and 34 OLP), and 29 controls. sLDH values were higher in the OSCC, followed by the OPMD and CG groups, although no significant differences were observed. In the OSCC group, larger tumor size was associated with higher sLDH levels. In the OLP group, sLDH values were higher in patients with symptomatic lesions than in patients with only white lesions, but not significantly. No associations were observed between sLDH and the type of OL (homogeneous vs. non-homogeneous) and the degree of dysplasia. When analyzing periodontal variables among OSCC, OPMD and CG, periodontal probing depth (PPD) and bleeding on probing were significantly higher in the OSCC group, while the plaque index was higher in OPMD patients. The linear regression model for sLDH in the total group identified age and PPD as significant predictors of sLDH levels. Discussion: Although sLDH values were higher in OSCC and OPMD patients than in a CG, the results do not support the use of sLDH as a reliable prognostic biomarker of malignancy. Future studies need to consider other factors that may influence sLDH levels, such as age and periodontal status. López-Pintor RM, González-Serrano J, Vallina C, Ivaylova Serkedzhieva K, Virto L, Nuevo P, Caponio VCA, Iniesta M, Rodríguez Santamarta T, Lequerica Fernández P, Iglesias Velázquez Ó, Hernández G, de Vicente JC. Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders. Front. Oral. Health 2025;5:1525936. doi: 10.3389/froh.2024.1525936 10.3389/froh.2024.1525936 https://hdl.handle.net/20.500.14352/113225 2673-4842 https://doi.org/10.3389/froh.2024.1525936 https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2024.1525936/full Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders