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oai:docta.ucm.es:20.500.14352/1140982025-03-18T12:06:03Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Gonzalo, Elena author Toldos González, Óscar author Pablos Álvarez, José Luis author Galindo Izquierdo, María author 2012 Introduction Microthrombosis is often observed in lupus nephritis (LN) lesions, but its clinical significance is unknown. We evaluated the clinicopathologic correlations of renal microthrombosis and inflammatory markers in LN. Methods Kidney biopsies from 58 patients with systemic lupus erythematosus (SLE) proliferative nephritis were analyzed with immunohistochemistry (IHC) for intravascular platelet aggregates (CD61), macrophagic infiltration (CD68), and activated complement deposition (C4d). Clinical data at the time of kidney biopsy and follow-up were analyzed with regard to pathologic IHC data. Results Microthrombosis was present in 52% of the tissues. It was significantly more prevalent in patients with antiphospholipid antibodies (aPLs) (62% versus 42%). The presence of microthrombosis significantly correlated with higher macrophagic infiltration. Macrophagic infiltration but not microthrombosis was significantly correlated with C4d deposition. Only macrophagic infiltration showed a correlation with SLE and renal activity (proteinuria and active sediment), whereas neither the presence of CD61+ microthrombi nor the extent of C4d deposition correlated with LN severity or outcome. Conclusions Microthrombosis is associated with higher macrophagic infiltration in LN but does not seem to increase independently the severity of renal damage. Macrophagic infiltration was the best marker of SLE and renal activity in this LN series. Gonzalo E, Toldos O, Martínez-Vidal MP, Ordoñez MC, Santiago B, Fernández-Nebro A, Loza E, García I, León M, Pablos JL, Galindo M. Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis. Arthritis Res Ther. 2012 May 28;14(3):R126. 1478-6354 10.1186/ar3856 https://hdl.handle.net/20.500.14352/114098 https://arthritis-research.biomedcentral.com/articles/10.1186/ar3856 Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis