2026-06-29T07:31:52Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1141242025-01-15T01:05:42Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Fernández Vázquez, María Inmaculada author Ulloa, Esperanza author Colina Ruiz-Delgado, Francisco author Abradelo De Usera, Manuel author Jiménez Romero, Luis Carlos author Gimeno, Alberto author Meneu Díaz, Juan Carlos author Lumbreras Bermejo, Carlos Juan author Solís Herruzo, José Antonio author Moreno González, Enrique 2025-01-14T08:41:54Z 2025-01-14T08:41:54Z 2009-07-29 Fernández I, Ulloa E, Colina F, Abradelo M, Jiménez C, Gimeno A, Meneu JC, Lumbreras C, Solís-Herruzo JA, Moreno E. Incidence, risk factors, and outcome of chronic rejection during antiviral therapy for posttransplant recurrent hepatitis C. Liver Transpl. 2009 Aug;15(8):948-55. doi: 10.1002/lt.21780 1527-6465 10.1002/lt.21780 https://hdl.handle.net/20.500.14352/114124 https://doi.org/10.1002/lt.21780 19642125 https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/lt.21780https://pubmed.ncbi.nlm.nih.gov/19642125/ Antiviral therapy for recurrent hepatitis C in liver transplantation has been associated with the development of chronic rejection. The aim of this study was to assess the incidence, evolution, and risk factors associated with the development of chronic rejection during posttransplant hepatitis C virus antiviral therapy. Seventy-nine patients with posttransplant recurrent hepatitis C who were treated with pegylated interferon and ribavirin were prospectively followed. Liver biopsy was performed before antiviral therapy was initiated and when liver tests worsened during therapy. Pretransplant and posttransplant factors were analyzed as potential risk factors for the development of chronic rejection. Seven of 79 patients (9%) developed chronic rejection during antiviral therapy. The mean time from the start of treatment to the development of chronic rejection was 5.8 months (3–12 months). An analysis of factors associated with the development of chronic rejection showed that the use of cyclosporine as immunosuppression therapy (6 of 19 patients who received cyclosporine developed chronic rejection in comparison with only 1 of 57 patients who received tacrolimus; P = 0.0013), achievement of sustained virological response (P = 0.043), and ribavirin discontinuation (P = 0.027) were associated with the development of chronic rejection. In conclusion, the development of chronic rejection during posttransplant pegylated interferon and ribavirin therapy is a severe complication. The use of cyclosporine, ribavirin discontinuation, and viral infection elimination seem to be associated with the development of this complication. Liver Transpl 15:948–955, 2009. © 2009 AASLD. eng Incidence, risk factors, and outcome of chronic rejection during antiviral therapy for posttransplant recurrent hepatitis C journal article 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URL https://docta.ucm.es/bitstreams/1be4f2cf-7daa-4244-999c-b370e0fc90d3/download File MD5 f47c2378b844c980087ad2afc6d66e50 234772 application/pdf Liver Transplantation 2009.pdf