2026-08-22T00:38:05Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1142252026-01-21T00:58:51Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Pablos Álvarez, José Luis author Galindo Izquierdo, María author Castrejón Fernández, Isabel author Álvaro-Gracia Álvaro, José María author Fernandez-Nebro, Antonio 2025-01-14T11:38:30Z 2025-01-14T11:38:30Z 2020 Pablos JL, Galindo M, Carmona L, Lledó A, Retuerto M, Blanco R, Gonzalez-Gay MA, Martinez-Lopez D, Castrejón I, Alvaro-Gracia JM, Fernández Fernández D, Mera-Varela A, Manrique-Arija S, Mena Vázquez N, Fernandez-Nebro A; RIER Investigators Group; RIER investigators group. Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study. Ann Rheum Dis. 2020 Dec;79(12):1544-1549. 0003-4967 10.1136/annrheumdis-2020-218296 https://hdl.handle.net/20.500.14352/114225 https://doi.org/10.1136/annrheumdis-2020-218296 Objectives: The impact of inflammatory rheumatic diseases on COVID-19 severity is poorly known. Here, we compare the outcomes of a cohort of patients with rheumatic diseases with a matched control cohort to identify potential risk factors for severe illness. Methods: In this comparative cohort study, we identified hospital PCR+COVID-19 rheumatic patients with chronic inflammatory arthritis (IA) or connective tissue diseases (CTDs). Non-rheumatic controls were randomly sampled 1:1 and matched by age, sex and PCR date. The main outcome was severe COVID-19, defined as death, invasive ventilation, intensive care unit admission or serious complications. We assessed the association between the outcome and the potential prognostic variables, adjusted by COVID-19 treatment, using logistic regression. Results: The cohorts were composed of 456 rheumatic and non-rheumatic patients, in equal numbers. Mean age was 63 (IQR 53-78) years and male sex 41% in both cohorts. Rheumatic diseases were IA (60%) and CTD (40%). Most patients (74%) had been hospitalised, and the risk of severe COVID-19 was 31.6% in the rheumatic and 28.1% in the non-rheumatic cohort. Ageing, male sex and previous comorbidity (obesity, diabetes, hypertension, cardiovascular or lung disease) increased the risk in the rheumatic cohort by bivariate analysis. In logistic regression analysis, independent factors associated with severe COVID-19 were increased age (OR 4.83; 95% CI 2.78 to 8.36), male sex (1.93; CI 1.21 to 3.07) and having a CTD (OR 1.82; CI 1.00 to 3.30). Conclusion: In hospitalised patients with chronic inflammatory rheumatic diseases, having a CTD but not IA nor previous immunosuppressive therapies was associated with severe COVID-19. eng Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study journal article 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URL https://docta.ucm.es/bitstreams/84153c90-5f71-43da-b93e-051782298b27/download File MD5 056056f72e03ed2f8901bae5bbc4e554 781340 application/pdf Clinical outcomes COVID_VoR.pdf URL https://docta.ucm.es/bitstreams/8f43b42c-0c94-4365-88ae-402f2b064f21/download File MD5 fea954fe97ca6c9a4378e982a4547e81 438421 application/pdf Clinical_outcomes_AM.pdf URL https://docta.ucm.es/bitstreams/71ba45a4-91fc-4bfb-be67-0525c0416ea1/download File MD5 7f432ce2b1828d48fc653a359aa25674 42156 text/plain Resultados clínicos de pacientes hospitalizados con COVID-19 y enfermedades reumáticas inflamatorias.pdf.txt