2026-06-29T01:30:22Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1142262025-01-15T01:06:55Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Fraguas Herráez, David author Díaz Caneja, Covadonga M. author Corripio, Iluminada author González Pinto, Ana author Lobo, Antonio author Bioque, Miguel author Cuesta, Manuel J. author Sanjuán, Julio author Rodríguez Toscano, Elisa author Arias, Bárbara author Sarró, Salvador author Cabrera, Bibiana author Bulbena, Antoni author Vieta, Eduard author Castro Fornieles, Josefina author Arango López, Celso author Bernardo, Miguel author Parellada Redondo, María José 2025-01-14T11:38:41Z 2025-01-14T11:38:41Z 2017 Fraguas, D., Díaz-Caneja, C. M., Corripio, I., González-Pinto, A., Lobo, A., Bioque, M., Cuesta, M. J., Sanjuán, J., Rodríguez-Toscano, E., Arias, B., Sarró, S., Cabrera, B., Bulbena, A., Vieta, E., Castro-Fornieles, J., Arango, C., Bernardo, M., & Parellada, M. (2017). Gene-environment interaction as a predictor of early adjustment in first episode psychosis. Schizophrenia Research, 189, 196-203. https://doi.org/10.1016/j.schres.2017.02.021 0920-9964 10.1016/j.schres.2017.02.021 https://hdl.handle.net/20.500.14352/114226 1573-2509 https://doi.org/10.1016/j.schres.2017.02.021 28262436 https://www.sciencedirect.com/science/article/pii/S092099641730110X?via%3Dihubhttps://www.sciencedirect.com/journal/schizophrenia-research Background: This study aims to explore the gene-environment interaction hypothesis applied to pre-symptomatic neurodevelopmental phenotypes of first episode psychosis (FEP), that is, genetic factors might increase vulnerability to the effects of environmental adverse conditions occurring at later stages of development. Methods:We constructed a schematic ‘two-hit’ model, with Val/Val homozygosity for the catechol-O-methyltransferase (COMT) Val158Met polymorphism as the ‘first hit’ and history of obstetric complications and parental socioeconomic status as ‘second hits’. Early adjustment,measured using the Premorbid Adjustment Scale,was considered the main outcome. The study population comprised 221 adolescents and adults with FEP and 191 sex- and agematched controls. Results: The interaction between the Val/Val COMT genotype and a positive history of obstetric complications plus lowparental socioeconomic status was significantly associated with poorer early adjustment. These results were observed both in FEP individuals and in controls, and remained significant after controlling for age, sex, and diagnosis. Conclusions: Individuals carrying Val/Val seem to bemore sensitive to the synergistic effect of environmental factors acting early in neurodevelopment, which leads to vulnerability phenotypes such as impaired early adjustment. eng Gene-environment interaction as a predictor of early adjustment in first episode psychosis journal article 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URL https://docta.ucm.es/bitstreams/df481ae1-14d7-441e-8cfb-1639373d4a92/download File MD5 1f8b3d5cb838870c4446452522860248 418633 application/pdf 2017_Fraguas_Gene environment interaction as a predictor.pdf