2026-06-29T02:39:03Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1142452025-03-18T13:53:16Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Hirano-Kawamoto, Ai author Honkura, Yohei author Murakami, Gen author Abe, Shinichi author Rodríguez Vázquez, José Francisco author Katori, Yukio 2025-01-14T12:03:48Z 2025-01-14T12:03:48Z 2024-12-02 Hirano-Kawamoto, A., Honkura, Y., Murakami, G. et al. Development and growth of fasciae in and around the esophageal hiatus: a histological study using human fetuses. Surg Radiol Anat 47, 16 (2025). https://doi.org/10.1007/s00276-024-03517-4 0930-1038 0930-1038 10.1007/s00276-024-03517-4 https://hdl.handle.net/20.500.14352/114245 1279-8517 https://doi.org/10.1007/s00276-024-03517-4 39621082 https://link.springer.com/article/10.1007/s00276-024-03517-4#citeashttps://pubmed.ncbi.nlm.nih.gov/39621082/ Purpose An entire fascial configuration at the esophageal hiatus might not be demonstrated histologically. According to observations of human fetus histology, the aim of this study was to consider which factor is likely to make the individual variation in adults. Methods We observed frontal histological sections containing the esophageal hiatus from 12 midterm fetuses at 12–16 weeks (crown-rump length: CRL, 85–137 mm) and 10 near-term fetuses at 26–30 weeks (CRL, 214–250 mm). Results At midterm, the transversalis fascia covering the diaphragm turned upward to join the adventitia of the left aspect of the esophagus: thus, the upper leaflet of the phreno-esophageal membrane was established first. A connection between the adventitia and endothoracic fascia (i.e., the upper leaflet of the PEM) was deleyed in the right. At near-term, both the transversalis and endothoracic fasciae often joined the adventitia in the left side but not in the right side. Therefore, fascial development advanced in the left side as well as the inferior side of the hiatus. The foregut-midgut junction, suggested with cytokeratin 5/6 immunostaining, was located in the hiatus. Conclusion Development and growth of the phreno-esophageal membrane showed left/right and superior/inferior differences. The transiently-appeared pleural recess, the upward protruding right crus of diaphragm and, the right liver and adrenal extending upward seemed to disturb the fascial connection to the adventitia in the right and/or superior side. Individual variations in the fascial configuration at the hiatus might occur due to the site-dependent delay of the establishment of structures. eng Development and growth of fasciae in and around the esophageal hiatus: a histological study using human fetuses journal article 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URL https://docta.ucm.es/bitstreams/176c934f-a656-4dfb-9d06-309c789f2de7/download File MD5 f336430b156e7f648a58832d5fd23c97 5559359 application/pdf Development and growth of fasciae in and around the esophageal hiatus.pdf URL https://docta.ucm.es/bitstreams/47d5e1c0-79ce-45ee-9706-baf540a05867/download File MD5 22c0cd95e3d778511e776df58b6f4b5a 26907 text/plain Development and growth of fasciae in and around the esophageal hiatus.pdf.txt