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oai:docta.ucm.es:20.500.14352/1150312025-09-01T17:36:24Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Santmartí-Oliver, M author Bazal-Bonelli, S author Sánchez-Labrador, L author Beca-Campoy, T author Pérez-González, F author Cobo Vázquez, Carlos author Madrigal Martínez-Pereda, Cristina María author Meniz García, Cristina María author 2024 Background: Sutures have been the standard flap closure method of choice following mandibular third molar surgery but can lead to some complications. Tissue adhesives, including cyanoacrylate, have emerged as alternative flap closure method in this surgery to overcome such drawbacks. However, limited clinical trials can be found. Therefore, the aim of this clinical study was to compare two methods of flap closure in mandibular third molar surgery, cyanoacrylate and 4/0 silk sutures, by assessing post-operative outcome measures (pain, swelling, trismus, and healing) and patient-reported outcome measures (PROMs). Material and methods: A randomized split-mouth clinical trial was designed, in which mandibular third molar (M3M) extractions were performed, where the control side flap was closed with 4/0 silk sutures and the test side flap with cyanoacrylate. Swelling, pain, trismus, healing, and PROMs were recorded post-operatively. These variables were analyzed by means of the nonparametric Mann-Whitney U test, using SPSS statistical software version 28.0.0 (IBM® SPSS®, Chicago, IL, USA). For all results, a 95% confidence interval was recorded (significance level p < 0.05, two-tailed). Results: A total of 17 patients were recruited and 34 mandibular third molar extractions were performed. No statistically significant differences were found in terms of swelling, pain, trismus, healing, and PROMs between both groups (p<0.05). Conclusions: No statistically significant differences were found between flap closure with 4/0 silk sutures and cyanoacrylate, in terms of surgical post-operative outcomes and PROMs. However, further studies with larger sample sizes are required to be able to affirm it with greater certainty. Santmartí-Oliver M, Bazal-Bonelli S, Sánchez-Labrador L, Beca-Campoy T, Pérez-González F, Cobo-Vázquez CM, Madrigal Martínez-Pereda C, Meniz-García C. Cyanoacrylate versus suture as flap closure methods in mandibular third molar surgery: a split-mouth randomized controlled clinical study. Med Oral Patol Oral Cir Bucal. 2024 Jul 1;29(4):e458-e467. doi: 10.4317/medoral.26375 1698-4447 10.4317/medoral.26375 https://hdl.handle.net/20.500.14352/115031 1698-6946 https://doi.org/10.4317/medoral.26375 38907642 https://www.medicinaoral.com/medoralfree01/aop/26375.pdf https://pubmed.ncbi.nlm.nih.gov/38907642/ Cyanoacrylate versus suture as flap closure methods in mandibular third molar surgery: a split-mouth randomized controlled clinical study