2026-06-29T02:38:10Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1154412025-03-18T13:54:30Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Carracedo Rodríguez, Juan Gonzalo
author
García-Gonzalo, Cristina
author
Perez-Luque, Maria A.
author
Martínez-Aguila, Alejandro
author
Carpena-Torres, Carlos
2025-01-21T16:26:05Z
2025-01-21T16:26:05Z
2024-04
Carracedo G, Garcia-Gonzalo C, Perez-Luque MA, Martinez-Aguila A, Carpena-Torres C. Efficacy and safety of artificial tears containing Artemia salina extract with dinucleotides for dry eye. Clin Exp Optom. 2024 Apr 23:1-7. doi: 10.1080/08164622.2024.2341841. Epub ahead of print. PMID: 38653499.
10.1080/08164622.2024.2341841
https://hdl.handle.net/20.500.14352/115441
https://doi.org/10.1080/08164622.2024.2341841
Clinical relevance: This clinical trial was conducted as part of the marketing procedures for a medical device comprising artificial tears containing Artemia salina extract with dinucleotides. These molecules previously demonstrated secretagogue properties by enhancing the production of aqueous, mucinous, and lipidic components of the tears.
Background: After confirming the efficacy of artificial tears containing Artemia salina extract in an animal model, this study proceeded to evaluate their efficacy and safety on dry eye participants.
Methods: A randomised controlled clinical trial was performed on 36 dry eye participants (41.6 ± 20.6 years). Half of the participants were treated with saline solution as a placebo for four weeks, while the other half were treated with artificial tears containing Artemia salina, randomly assigned. After a wash-out period of two weeks, the treatments were crossed for another four weeks. Participants were assessed at baseline and after one week, two weeks, and four weeks. Efficacy variables were: eye dryness frequency (primary), eye comfort, visual satisfaction, tear secretion, tear break-up time, corneal staining, conjunctival staining, and conjunctival hyperaemia. Safety variables were: high- and low-contrast visual acuity, intraocular pressure, and eye fundus images analysis.
Results: Compared with the baseline, the saline solution showed no significant changes in any of the studied variables after four weeks of treatment (p ≥ 0.05). However, the topical instillation of the artificial tears with Artemia salina for four weeks significantly improved eye dryness frequency (p = 0.014) and corneal staining (p = 0.010). No systemic or ocular adverse events were reported during the clinical trial.
Conclusion: The topical instillation of artificial tears containing Artemia salina in mild to moderate dry eye participants for four weeks slightly improved their symptoms related to eye dryness frequency and reduced corneal damage, with no undesirable side effects observed.
eng
Efficacy and safety of artificial tears containing Artemia salina extract with dinucleotides for dry eye
journal article
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Efficacy_and_safety_of_artificial_tears_containing_Artemia_salina_extract_with_dinucleotides.pdf
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Efficacy_and_safety_of_artificial_tears_containing_Artemia_salina_extract_with_dinucleotides.pdf.txt