2026-06-29T07:29:53Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1156522025-08-26T13:02:29Zcom_20.500.14352_14col_20.500.14352_15

A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice Cediel, R Contreras, J Murillo-Cuesta, S Hernandez-Sanchez, C Cerdan, S Varela-Nieto, I Riquelme Arias, Gerardo Rodríguez De La Rosa, José Carlos Hernández Sánchez, Lucía Zubeldia Ortuño, José Manuel 612 Igf1−/− null mouse Aging Auditory brainstem responses Deafness In vivo brain imaging Insulin-like factors Presbycusis Sensorineural deafness Fisiología 3299 Otras Especialidades Médicas Insulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a key role during the late development of the nervous system. Human IGF1 mutations cause profound deafness, poor growth and mental retardation. Accordingly, Igf1(-/-) null mice are dwarfs that have low survival rates, cochlear alterations and severe sensorineural deafness. Presbycusis (age-related hearing loss) is a common disorder associated with aging that causes social and cognitive problems. Aging is also associated with a decrease in circulating IGF-I levels and this reduction has been related to cognitive and brain alterations, although there is no information as yet regarding the relationship between presbycusis and IGF-I biodisponibility. Here we present a longitudinal study of wild type Igf1(+/+) and null Igf1(-/-) mice from 2 to 12 months of age comparing the temporal progression of several parameters: hearing, brain morphology, cochlear cytoarchitecture, insulin-related factors and IGF gene expression and IGF-I serum levels. Complementary invasive and non-invasive techniques were used, including auditory brainstem-evoked response (ABR) recordings and in vivo MRI brain imaging. Igf1(-/-) null mice presented profound deafness at all the ages studied, without any obvious worsening of hearing parameters with aging. Igf1(+/+) wild type mice suffered significant age-related hearing loss, their auditory thresholds and peak I latencies augmenting as they aged, in parallel with a decrease in the circulating levels of IGF-I. Accordingly, there was an age-related spiral ganglion degeneration in wild type mice that was not evident in the Igf1 null mice. However, the Igf1(-/-) null mice in turn developed a prematurely aged stria vascularis reminiscent of the diabetic strial phenotype. Our data indicate that IGF-I is required for the correct development and maintenance of hearing, supporting the idea that IGF-I-based therapies could contribute to prevent or ameliorate age-related hearing loss. Ministerio de Ciencia e Innovacion (España) Fundacion Mutua Madrileña Depto. de Medicina Fac. de Medicina TRUE pub 2025-01-22T16:33:58Z 2025-01-22T16:33:58Z 2010 journal article AM https://hdl.handle.net/20.500.14352/115652 XXXX-XXXX 10.3389/fnana.2010.00027 eng info:eu-repo/grantAgreement/MICINN//SAF2008-00470/ES/MODELOS ANIMALES Y CELULARES PARA EL ESTUDIO DE LA HIPOACUSIA NEUROSENSORIAL, METABOLICA Y POR EXPOSICION A RUIDO EXCESIVO/ Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf Frontiers