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Martínez Martínez, Ernesto Cachofeiro Ramos, María Victoria López-Andrés N 2025-01-23T12:47:27Z 2025-01-23T12:47:27Z 2015-08-15 Martínez-Martínez E, Cachofeiro V, Rousseau E, Álvarez V, Calvier L, Fernández-Celis A, Leroy C, Miana M, Jurado-López R, Briones AM, Jaisser F, Zannad F, Rossignol P, López-Andrés N. Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation. Mol Cell Endocrinol. 2015 Aug 15;411:20-7. doi: 10.1016/j.mce.2015.04.007. Epub 2015 Apr 17. PMID: 25896545. 0303-7207 10.1016/j.mce.2015.04.007 https://hdl.handle.net/20.500.14352/115845 1872-8057 https://doi.org/10.1016/j.mce.2015.04.007 25896545 https://pubmed.ncbi.nlm.nih.gov/25896545/ https://www.sciencedirect.com/science/article/pii/S0303720715001732 Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients. The aim of this study was to investigate the interactions between IL-33/ST2 system and Aldosterone in adipose tissue. Rats fed a high fat diet presented increased sST2 expression, diminished IL-33/sST2 ratio and enhanced levels of differentiation and inflammation in adipose tissue as compared to controls. A similar pattern was observed in adipose tissue from C57BL/6 Aldosterone-treated mice. In both animal models, Aldosterone was correlated with sST2. Treatment of 3T3-L1 adipocytes with IL-33 delayed adipocyte differentiation diminished lipid accumulation and decreased inflammation. Aldosterone decreased IL-33 and increased sST2 expressions in differentiated adipocytes. Aldosterone-induced adipocyte differentiation and inflammation were blocked by IL-33 treatment, but sST2 did not exert any effects. The crosstalk between IL-33/ST2 and Aldosterone could be relevant in the metabolic consequences of obesity. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ restricted access Attribution-NonCommercial-NoDerivatives 4.0 International Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation journal article