2026-06-29T07:40:12Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1160762025-03-18T13:55:41Zcom_20.500.14352_14col_20.500.14352_15

Prognostic value of ki-67 according to age in patients with triple-negative breast cancer Zenzola, Víctor Cabezas-Quintario, , María Antonia Arguelles, Miguel Pérez-Fernández, Elia Izarzugaza, Y Correa, Andrea García-Foncillas, Jesús 616-006.04 Age; Ki-67 Prognosis Triple-negative breast cancer Ciencias Biomédicas 32 Ciencias Médicas Purpose: The prognostic value of Ki-67 in triple-negative breast cancer (TNBC) is yet unclear because the cut-off points employed differ widely and its predictive effect may vary according to age. The purpose of this study was to analyze the role of Ki-67 among patients with TNBC, and determine the optimal Ki-67 cut-off point to demonstrate its prognostic relevance associated with patient age and treatment strategy. Methods/patients: 201 consecutive patients treated for primary TNBC from 1999 to 2014 were analyzed. Clinicopathological characteristics and outcomes were compared between patients treated with neoadjuvant or adjuvant chemotherapy. We used time-dependent receiver operating characteristic (ROC) curve and time-dependent area under the ROC curve (AUC) to evaluate the discriminative ability of Ki-67 at 3 and 5 years of follow-up. A Ki-67 cut-off point that maximized sensibility and specificity was established. Interaction effect between age and Ki-67 on disease-free survival (DFS) and overall survival (OS) was evaluated by stratified analysis. Results: According to the coordinates of the ROC curves, the best cut-off point for Ki-67 was 60% (high/low). In the whole group, there was not a statistically significant association between Ki-67 and OS and DFS, using a cut-off point of 60%. In multivariate analysis (COX proportional hazards regression), for DFS high Ki-67 (> 60%) was a poor prognostic factor in patients > 40 years old and a better prognostic factor among the patients < 40 years old. Conclusion: Prognostic value of Ki-67 in TNBC, using a cut-off point of 60%, may vary depending on age. Depto. de Medicina Legal, Psiquiatría y Patología Fac. de Medicina TRUE pub 2025-01-24T15:52:26Z 2025-01-24T15:52:26Z 2018-04-18 journal article VoR https://hdl.handle.net/20.500.14352/116076 1699-048X 1699-3055 10.1007/s12094-018-1877-5 eng Zenzola V, Cabezas-Quintario MA, Arguelles M, Pérez-Fernández E, Izarzugaza Y, Correa A, et al. Prognostic value of Ki-67 according to age in patients with triple-negative breast cancer. Clinical and Translational Oncology [Internet]. 2018 Apr 18;20(11):1448–54. Available from: http://dx.doi.org/10.1007/s12094-018-1877-5 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ restricted access application/pdf Springer Link