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oai:docta.ucm.es:20.500.14352/1161202025-09-12T16:41:09Zcom_20.500.14352_14col_20.500.14352_18

00925njm 22002777a 4500 dc Ballesteros Sanabria, Laura author Peláez Prestel, Héctor Fernando author Reche Gallardo, Pedro Antonio author Lafuente Duarte, María Esther author 2023 EPIPOX is a specialized online resource intended to facilitate the design of epitope-based vaccines against orthopoxviruses. EPIPOX is built upon a collection of T cell epitopes that are shared by eight pathogenic orthopoxviruses, including variola minor and major strains, monkeypox, cowpox, and vaccinia viruses. In EPIPOX, users can select T cell epitopes attending to the predicted binding to distinct major histocompatibility molecules (MHC) and according to various features that may have an impact on epitope immunogenicity. Among others, EPIPOX allows to discern epitopes by their structural location in the virion and the temporal expression of the counterpart antigens. Overall, the annotations in EPIPOX are optimized to facilitate the rational design of T cell epitope-based vaccines. In this chapter, we describe the main features of EPIPOX and exemplify its use, retrieving orthopoxvirus-specific T cell epitopes with features set to enhance their immunogenicity. EPIPOX is available for free public use at http://bio.med.ucm.es/epipox/ . Ballesteros-Sanabria L, Pelaez-Prestel HF, Reche PA, Lafuente EM. EPIPOX: A Resource Facilitating Epitope-Vaccine Design Against Human Pathogenic Orthopoxviruses. Methods Mol Biol. 2023;2673:175-185. doi:10.1007/978-1-0716-3239-0_12 978-1-0716-3238-3 978-1-0716-3239-0 1064-3745 10.1007/978-1-0716-3239-0_12 https://hdl.handle.net/20.500.14352/116120 https://doi.org/10.1007/978-1-0716-3239-0_12 https://pubmed.ncbi.nlm.nih.gov/37258914/ EPIPOX: A Resource Facilitating Epitope-Vaccine Design Against Human Pathogenic Orthopoxviruses