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oai:docta.ucm.es:20.500.14352/1161452025-03-18T13:43:27Zcom_20.500.14352_14col_20.500.14352_15

Torres Gómez, Álvaro Cabañas Gutiérrez, Carlos Lafuente Duarte, María Esther 2025-01-27T08:20:37Z 2025-01-27T08:20:37Z 2020-04-30 Torres-Gomez, A., Cabañas, C., & Lafuente, E. M. (2020). Phagocytic Integrins: Activation and Signaling. Frontiers in immunology, 11, 738. https://doi.org/10.3389/fimmu.2020.00738 1664-3224 10.3389/fimmu.2020.00738 https://hdl.handle.net/20.500.14352/116145 https://doi.org/10.3389/fimmu.2020.00738 32425937 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00738/full https://pubmed.ncbi.nlm.nih.gov/32425937/ Phagocytic integrins are endowed with the ability to engulf and dispose of particles of different natures. Evolutionarily conserved from worms to humans, they are involved in pathogen elimination and apoptotic and tumoral cell clearance. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. However, there are still some aspects of the regulation of the phagocytic process that need to be clarified. Here, we have revised the molecular events controlling phagocytic integrin activation and the downstream signaling driving particle engulfment, and we have focused particularly on αMβ2/CR3, αXβ2/CR4, and a brief mention of αVβ5/αVβ3integrins. eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Phagocytic Integrins: Activation and Signaling journal article