2026-06-01T01:59:41Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1162562025-03-18T13:31:57Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Moreno Ruiz, María del Carmen author García Bueno, Borja author Bioque M author Mac-Dowell Mata, Karina Soledad author Santabárbara J author Martínez-Cengotitabengoa M author Sáiz PA author Berrocoso E author Gassó P author Fe Barcones M author González-Pinto A author Parellada Redondo, María José author Bobes J author Micó JA author Bernardo M author Leza Cerro, Juan Carlos author FLAMM-PEPs study author 2014 Background: Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to identify potential risk/protective factors and associations with symptom severity. Methods: Eighty-five subjects were followed during 12 months and the determination of the same pro-/antiinflammatory mediators was carried out in plasma and peripheral blood mononuclear cells. Multivariate logistic regression analyses were used to identify risk/protective factors. Multiple linear regression models were performed to detect the change of each biological marker during follow-up in relation to clinical characteristics and confounding factors. Results: This study suggests a more severe systemic pro-/antiinflammatory deregulation than in earlier pathological stages in first psychotic episode, because not only were intracellular components of the inflammatory response increased but also the majority of soluble elements. Nitrite plasma levels and cyclooxygenase-2 expression in peripheral blood mononuclear cells are reliable potential risk factors and 15d-prostaglandin-J2 plasma levels a protection biomarker. An interesting relationship exists between antipsychotic dose and the levels of prostaglandin-E2 (inverse) and 15d-prostaglandin-J2 (direct). An inverse relationship between the Global Assessment of Functioning scale and lipid peroxidation is also present. Conclusions: Summing up, pro-/antiinflammatory mediators can be used as risk/protection biomarkers. The inverse association between oxidative/nitrosative damage and the Global Assessment of Functioning scale, and the possibility that one of the targets of antipsychotics could be the restoration of the pro-/antiinflammatory balance support the use of antiinflammatory drugs as coadjuvant to antipsychotics. García-Bueno B, Bioque M, MacDowell KS, Santabárbara J, Martínez-Cengotitabengoa M, Moreno C, Sáiz PA, Berrocoso E, Gassó P, Fe Barcones M, González-Pinto A, Parellada M, Bobes J, Micó JA, Bernardo M, Leza JC; FLAMM-PEPs study, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Pro-/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study. Int J Neuropsychopharmacol. 2014 Oct 31;18(2):pyu037. doi: 10.1093/ijnp/pyu037 1469-5111 10.1093/ijnp/pyu037 https://hdl.handle.net/20.500.14352/116256 https://doi.org/10.1093/ijnp/pyu037 25577666 https://academic.oup.com/ijnp Pro-/Antiinflammatory Dysregulation in Early Psychosis: Results from a 1-Year Follow-Up Study