2026-06-27T12:36:13Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1163852025-03-14T15:38:20Zcom_20.500.14352_14col_20.500.14352_15

Merino Martín, José Joaquín Cabaña-Muñoz, María Eugenia Parmigiani-Izquierdo, José María Camacho Alonso, Fabio 2025-01-27T15:47:52Z 2025-01-27T15:47:52Z 2019 Cabaña-Muñoz, María Eugenia, et al. «Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams». Journal of Clinical Medicine, vol. 8, n.o 1, enero de 2019, p. 86. DOI.org (Crossref), https://doi.org/10.3390/jcm8010086. 10.3390/jcm8010086 https://hdl.handle.net/20.500.14352/116385 https://doi.org/10.3390/jcm8010086 https://pubmed.ncbi.nlm.nih.gov/30642082/ Abstract Introduction: the biological safety of dental biomaterials has been questioned in human studies. Material and methods: Several heavy metals/oligoelements were compared by Inductive Coupled Mass Spectrometry (ICP-MS) in hair samples from 130 patients (n = 54 patients with long-term titanium dental implants and amalgams (A + I group), 51 patients with long-term dental amalgam alone (A group), as well as controls (n = 25: without dental materials) of similar age. All patients (except controls) had had titanium dental implants and/or dental amalgams for at least 10 years (average: 17). We evaluated whether A + I patients could present higher systemic malondialdehyde levels (MDA) as compared to the A group. Results: The A + I group have lower molybdenum levels (A + I) and reduced Mo/Co and Mo/Fe2+ ratios, which could predispose them to oxidative stress by raising MDA levels as compared to the A group alone; our findings suggest that higher Co levels could enhance oxidative stress in the A + I group. However, there were no differences on metals from titanium alloy (Ti-6Al), Cr from crowns or Hg2+, Sn, Zn2+, Cu2+ levels between the A + I and A groups. Conclusion: patients with long-term dental titanium and amalgams have systemic oxidative stress due to rising MDA levels and lower Mo/Co and Mo/Fe2+ ratios than those with amalgams alone. eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams journal article