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oai:docta.ucm.es:20.500.14352/1164262025-01-28T00:46:29Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc García Aguilar, Ana author Palomino Ruiz-Poveda, Olga María author Benito De Las Heras, Manuel R. author Guillén Viejo, Carlos author 2021 Polyphenols represent a group of secondary metabolites of plants which have been analyzed as potent regulators of multiple biological processes, including cell proliferation, apoptosis, and autophagy, among others. These natural compounds exhibit beneficial effects and protection against inflammation, oxidative stress, and related injuries including metabolic diseases, such as cardiovascular damage, obesity and diabetes, and neurodegeneration. This review aims to summarize the mechanisms of action of polyphenols in relation to the activation of autophagy, stimulation of mitochondrial function and antioxidant defenses, attenuation of oxidative stress, and reduction in cell apoptosis, which may be responsible of the health promoting properties of these compounds. García-Aguilar, A.; Palomino, O.; Benito, M.; Guillén, C. Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects. Antioxidants 2021, 10, 142. https://doi.org/10.3390/antiox10020142 10.3390/antiox10020142 https://hdl.handle.net/20.500.14352/116426 2076-3921 https://doi.org/10.3390/antiox10020142 Dietary polyphenols in metabolic and neurodegenerative diseases: Molecular targets in autophagy and biological effects