2026-06-28T20:30:34Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1167192025-03-18T12:50:32Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Castelo, Janire author Araujo-Aris, Sarai author Barriales, Diego author Tanner Pasco, Samuel author Seoane, Iratxe author Peña-Cearra, Ainize author Palacios, Ainhoa author Simó, Carolina author García-Cañas, Virginia author Khamwong, Muthita author Martín-Ruiz, Itziar author González-López, Monika author Bárcena, Laura author Martín Rodríguez, José Ezequiel author Lavín, José Luis author Gutiez, Naiara author Marcos, Raquel author Atondo, Estibaliz author Flores Landeira, Juana María author Rodríguez, Héctor 2025-01-28T19:06:41Z 2025-01-28T19:06:41Z 2024-12-15 Castelo, J., Araujo-Aris, S., Barriales, D., Tanner Pasco, S., Seoane, I., Peña-Cearra, A., … Rodríguez, H. (2024). The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation. Gut Microbes, 16(1). https://doi.org/10.1080/19490976.2024.2438829 1949-0984 10.1080/19490976.2024.2438829 https://hdl.handle.net/20.500.14352/116719 https://doi.org/10.1080/19490976.2024.2438829 Phloroglucinol is a key byproduct of gut microbial metabolism that has been widely used as a treatment for irritable bowel syndrome. Here, we demonstrate that phloroglucinol tempers macrophage responses to pro-inflammatory pathogens and stimuli. In vivo, phloroglucinol administration decreases gut and extraintestinal inflammation in murine models of inflammatory bowel disease and systemic infection. The metabolite induces modest modifications in the microbiota. However, the presence of an active microbiota is required to preserve its anti-inflammatory activity. Remarkably, the protective effect of phloroglucinol lasts partially at least 6 months. Single-cell transcriptomic analysis of bone marrow progenitors demonstrates the capacity of the metabolite to induce long-lasting innate immune training in hematopoietic lineages, at least partially through the participation of the receptor and transcription factor, aryl hydrocarbon receptor (AhR). Phloroglucinol induces alterations in metabolic and epigenetic pathways that are most prevalent in upstream progenitors as hallmarks of central trained immunity. These data identify phloroglucinol as a dietary-derived compound capable of inducing central trained immunity and modulating the response of the host to inflammatory insults. eng Attribution 4.0 International The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation journal article 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URL https://docta.ucm.es/bitstreams/cb1d78d0-5b2e-4efc-ad17-64dfebbc0b05/download File MD5 5129afe373eeed703dad424b51df89ab 8851155 application/pdf The microbiota metabolite phloroglucinol confers long-term protection against inflammation.pdf URL https://docta.ucm.es/bitstreams/44769a94-5b3c-42a8-948a-3a4f17a29788/download File MD5 4e22fba114e5a1f4e920a13e77a4af7f 96947 text/plain The microbiota metabolite phloroglucinol confers long-term protection against inflammation.pdf.txt