2026-06-07T13:53:52Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1168842025-03-18T14:48:26Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Merino Martín, José Joaquín author Montes, M. Luisa author Blanco, Almudena author Bustos, María J. author Oreja Guevara, Celia author Bayon, Carmen author Cuadrado, Antonio author Lubrini, Genny author Cambron, Irene author Munoz, Ainhoa author Cebolla, Susana author Gutierrez-Fernandez, María author Bernardino, José I. author Arribas, José R. author Fiala, Milan 2025-01-29T12:38:05Z 2025-01-29T12:38:05Z 2011-01 Merino Martín JJ, Montes ML, Blanco A, Bustos MJ, Oreja Guevara C, Bayón C, et al. Neuropatogénesis inducida por el virus del sida: estrategias terapéuticas frente a la neurodegeneración inducida por la glucoproteína gp120/Tat en el sistema nervioso central. RevNeurol [Internet]. 2011 [citado 29 de enero de 2025];52(02):101. Disponible en: https://www.imrpress.com/journal/RN/52/2/10.33588/rn.5202.2010185 10.33588/rn.5202.2010185 https://hdl.handle.net/20.500.14352/116884 https://doi.org/10.33588/rn.5202.2010185 https://www.neurologia.com/52/2/10.33588/rn.5202.2010185 Abstract Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen species (ROS) that eventually damage the neuron. Moreover, the neurotoxin Tat produces dendritic loss by interacting with the low-density lipoprotein receptor (LRP) and also overstimulates N-methyl D-aspartate receptors (NMDA). Furthermore, the aberrant interaction of glycoprotein gp120 with the CXCR4 chemokine receptor causes caspase-3-dependent apoptosis (ceramide is also released) activating apoptotic proteins (p53 and retinoblastoma), which are part of the neurotoxic mechanisms associated to neuronal dysfunction in neuroAIDS. Similarly, gliosis/microglial activation and the release of neurotoxic factors by infected monocytes with elevated amounts of certain chemokines in the cerebrospinal fluid (MCP-1 and fractalkine, among others) contribute to the neuropathogenesis of HIV-1. Alpha-synuclein and beta amyloid deposits have also been detected in post mortem brains of seropositives patients. In addition, there are studies have detected several systemic markers related with the degenerative effects of the virus and its neurotoxins on the central nervous system; such as osteopontin, CD163 and fractalkine, among others. Lastly, clinical trials have been conducted using protective strategies related that attempt to inhibit apoptotic proteins (GSK-3 beta), microglial activation inhibitors (minocycline), antioxidants (selegiline) or trophic factors (IGF-1, growth hormone or erythropoietin). These trials have shown that their treatments are beneficial and complementary to treat complications of HIV/AIDS. spa Attribution-NonCommercial-NoDerivatives 4.0 International HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system Neuropatogénesis inducida por el virus del sida: estrategias terapéuticas frente a la neurodegeneración inducida por la glucoproteína gp120/Tat en el sistema nervioso central journal article 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