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00925njm 22002777a 4500 dc Ferrer García, María Desamparados author Sánchez Barrueco, Álvaro author Martinez‐Beneyto, Yolanda author Mateos Moreno, María Victoria author Ausina-Márquez, Verónica author García-Vázquez, Elisa author Puche-Torres, Miguel author Forner Giner, María J author Campos González, Alfonso author Santillán Coello, Jessica M author Alcalá Rueda, Ignacio author Villacampa Aubá, José M author Cenjor Español, Carlos author López Velasco, Ana author Santolaya Abad, Diego author García‐Esteban, Sandra author Artacho, Alejandro author López‐Labrador, Xavier author Mira, A author 2021-12-22 Most public health measures to contain the COVID-19 pandemic are based on preventing the pathogen spread, and the use of oral antiseptics has been proposed as a strategy to reduce transmission risk. The aim of this manuscript is to test the efficacy of mouthwashes to reduce salivary viral load in vivo. This is a multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial that tests the effect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, povidone-iodine and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at baseline and 30, 60 and 120 min after the mouthrinse. A fifth group of patients used distilled water mouthrinse as a control. Eighty-four participants were recruited and divided into 12-15 per group. There were no statistically significant changes in salivary viral load after the use of the different mouthwashes. Although oral antiseptics have shown virucidal effects in vitro, our data show that salivary viral load in COVID-19 patients was not affected by the tested treatments. This could reflect that those mouthwashes are not effective in vivo, or that viral particles are not infective but viral RNA is still detected by PCR. Viral infectivity studies after the use of mouthwashes are therefore required. ( https://clinicaltrials.gov/ct2/show/NCT04707742 ; Identifier: NCT04707742). Ferrer MD, Barrueco ÁS, Martinez-Beneyto Y, Mateos-Moreno MV, Ausina-Márquez V, García-Vázquez E, Puche-Torres M, Giner MJF, González AC, Coello JMS, Rueda IA, Aubá JMV, Español CC, Velasco AL, Abad DS, García-Esteban S, Artacho A, López-Labrador X, Mira A. Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2. Sci Rep. 2021 Dec 22;11(1):24392. doi: 10.1038/s41598-021-03461-y 10.1038/s41598-021-03461-y https://hdl.handle.net/20.500.14352/117292 2045-2322 https://doi.org/10.1038/s41598-021-03461-y 34937855 https://www.nature.com/articles/s41598-021-03461-y https://pubmed.ncbi.nlm.nih.gov/34937855/ Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS‐CoV‐2