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00925njm 22002777a 4500 dc Villarejo Galende, Alberto author Llamas Velasco, Sara author Gómez Grande, Adolfo author Puertas Martín, Verónica author Contador, Israel author Sarandeses Fernández, María Del Pilar author González Sánchez, Marta author Trincado, Rocío author Pilkington, Patrick author Ruiz Solís, Sebastián author Pérez Martínez, David Andrés author Herrero San Martín, Alejandro author 2016-11-04 Primary progressive aphasia (PPA) is considered a heterogeneous syndrome, with different clinical subtypes and neuropathological causes. Novel PET biomarkers may help to predict the underlying neuropathology, but many aspects remain unclear. We studied the relationship between amyloid PET and PPA variant in a clinical series of PPA patients. A systematic review of the literature was performed. Patients with PPA were assessed over a 2-year period and classified based on language testing and the International Consensus Criteria as non-fluent/agrammatic (nfvPPA), semantic (svPPA), logopenic variant (lvPPA) or as unclassifiable (ucPPA). All patients underwent a Florbetapir (18-F) PET scan and images were analysed by two nuclear medicine physicians, using a previously validated reading method. Relevant studies published between January 2004 and January 2016 were identified by searching Medline and Web of Science databases. Twenty-four PPA patients were included (13 women, mean age 68.8, SD 8.3 years; range 54–83). Overall, 13/24 were amyloid positive: 0/2 (0%) nfvPPA, 0/4 (0%) svPPA, 10/14 (71.4%) lvPPA and 3/4 (75%) ucPPA (p = 0.028). The systematic review identified seven relevant studies, six including all PPA variants and one only lvPPA. Pooling all studies together, amyloid PET positivity was 122/224 (54.5%) for PPA, 14/52 (26.9%) for nfvPPA, 6/47 (12.8%) for svPPA, 101/119 for lvPPA (84.9%) and 12/22 (54.5%) for ucPPA. Amyloid PET may help to identify the underlying neuropathology in PPA. It could be especially useful in ucPPA, because in these cases it is more difficult to predict pathology. ucPPA is frequently associated with amyloid pathology. Villarejo-Galende, A., Llamas-Velasco, S., Gómez-Grande, A. et al. Amyloid pet in primary progressive aphasia: case series and systematic review of the literature. J Neurol 264, 121–130 (2017). https://doi.org/10.1007/s00415-016-8324-8 0340-5354 10.1007/s00415-016-8324-8 https://hdl.handle.net/20.500.14352/117636 1432-1459 https://doi.org/10.1007/s00415-016-8324-8 https://link.springer.com/article/10.1007/s00415-016-8324-8 Amyloid PET in primary progressive aphasia: case series and systematic review of the literature