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oai:docta.ucm.es:20.500.14352/1177742025-02-05T01:15:16Zcom_20.500.14352_14col_20.500.14352_15

Case-Control Study of the Risk Factors Linked to Respiratory Syncytial Virus Infection Requiring Hospitalization in Premature Infants Born at a Gestational Age of 33–35 Weeks in Spain Figueras Aloy, José Carbonell Estrany, Xavier Quero, José Rodríguez Fernández, Rosa María 616-053.32 616.98 respiratory syncytial virus premature hospitalization prophylaxis palivizumab Ciencias Biomédicas 32 Ciencias Médicas Background and objective: The aim of this study was to identify those risk factors most likely to lead to the development of RSV-related respiratory Infection and subsequent hospital admission among premature infants born at 33-35 WGA (FLIP study) Methods: This was a prospective case-control study. Cases (186) hospitalized for respiratory syncytial virus (RSV) illness were recruited from 50 participating Spanish hospitals during the 2002-2003 RSV season (October 2002-April 2003). Controls (371) were selected in June 2003 but born at same time as cases. Results: Of these cases, 20.5% were admitted to the intensive care unit intensive care unit, and 7.6% required mechanical ventilation. None of the patients died. Conditional logistic regression analysis adjusted for medical center demonstrated that the risk of RSV-related respiratory infection requiring hospital admission in preterm infants 33-35 weeks of gestation (WGA) in Spain was most often associated with absolute chronologic age at start of RSV season < or =10 weeks [ie, born between July 15 and December 15; odds ratio (OR), 3.95; 95% confidence interval (CI), 2.65-5.90], breast-feeding for < or =2 months total (OR 3.26; 95% CI 1.96-5.42), presence of > or =1 school age siblings (OR 2.85; 95% CI 1.88-4.33), > or =4 residents and visitors at home (discounting school age siblings and the case/control him/herself) (OR 1.91; 95% CI 1.19-3.07) and a family history of wheezing (OR 1.90; 95% CI 1.19-3.01). Conclusions: In premature infants born 33-35 WGA, certain underlying risk factors significantly increase the risk of RSV-related respiratory infection and hospitalization. Premature infants 33-35 WGA with additional risk factors should be considered for RSV prophylaxis with palivizumab. Depto. de Salud Pública y Materno - Infantil Fac. de Medicina TRUE pub 2025-02-04T09:03:22Z 2025-02-04T09:03:22Z 2004-09-01 journal article VoR https://hdl.handle.net/20.500.14352/117774 0891-3668 10.1097/01.inf.0000136869.21397.6b 1532-0987 eng Figueras-Aloy J, Carbonell-Estrany X, Quero J; IRIS Study Group. Case-control study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33-35 weeks in Spain. Pediatr Infect Dis J. 2004 Sep;23(9):815-20. doi: 10.1097/01.inf.0000136869.21397.6b. PMID: 15361718. restricted access application/pdf Lippincott Williams & Wilkins