2026-06-29T01:27:31Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1178622025-03-18T15:46:37Zcom_20.500.14352_14col_20.500.14352_22
Docta Complutense
advisor
Gómez Hernández, María De La Almudena
advisor
Escribano Illanes, Óscar
author
González López, Paula
2025-02-05T19:02:54Z
2025-02-05T19:02:54Z
2025-02-05
https://hdl.handle.net/20.500.14352/117862
Atherosclerosis is a chronic infl ammatory disease that affects medium- and large-sized arteries of different vascular beds and is characterized by thickening of the intima and media layer with loss of elasticity. Its basic lesion is the atheromatous plaque, which is mainly composed of lipids, fibrous tissue, and inflammatory cells, and goes through different stages (1). The atherosclerotic process begins with endothelial dysfunction, resulting in the uncoupling of endothelial nitric oxide synthase due to various causes such as the loss of the glycocalyx or the shear stress generated by blood fl ow on the endothelium...La aterosclerosis es una enfermedad inflamatoria crónica que afecta a las arterias de mediano y gran calibre de diferentes lechos vasculares y que se caracteriza por el engrosamiento de la capa íntima y media con pérdida de la elasticidad. Su lesión básica es la placa de ateroma compuesta fundamentalmente de lípidos, tejido fibroso y células inflamatorias, y pasa por diferentes estadios (1). El proceso aterosclerótico comienza con una disfunción endotelial que cursa con el desacoplamiento de la enzima óxido nítrico sintasa endotelial por distintas causas como la pérdida de glicocálix o el estrés de cizallamiento que genera la corriente sanguínea sobre el endotelio...
eng
The role of miR-143-3p, miR-155-5p, miR-15a-5p, and miR-199a-3p as key mediators in apoptosis, insulin resistance, and vascular inflammation in atherosclerosis Papel del miR-143-3p, miR-155-5p, miR-15a-5p y miR-199a-3p como mediadores clave de la apoptosis, la resistencia a insulina y la inflamación vascular en la aterosclerosis
doctoral thesis
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URL
https://docta.ucm.es/bitstreams/a5b3e987-9184-4833-823c-7a668b79e8bd/download
File
MD5
1a048a087f041bc6313ffbac6fca55e2
36090639
application/pdf
T45146.pdf
URL
https://docta.ucm.es/bitstreams/8f7fbe79-0d8b-470d-bbde-e6afe497d60e/download
File
MD5
34c09e95e105faa23ca80cb0290fa9b5
637983
text/plain
T45146.pdf.txt