2026-06-27T15:22:59Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1179002025-08-29T15:01:30Zcom_20.500.14352_14col_20.500.14352_15

Gómez García, Rosa Jiménez García, Rodrigo López De Andrés, Ana Isabel Hernández Barrera, Valentín Carabantes Alarcón, David Zamorano León, José Javier Cuadrado Corrales, María Natividad Jiménez Sierra, Ana Miguel Díez, Javier De 2025-02-07T07:49:04Z 2025-02-07T07:49:04Z 2024 Rosa María Gomez-Garcia , Rodrigo Jiménez-Garcia , Ana López-de-Andrés , Valentín Hernández-Barrera , David Carabantes-Alarcon , José J. Zamorano-León , Natividad Cuadrado-Corrales, Ana Jiménez-Sierra and Javier De-Miguel-Diez 10.3390/v16111749 https://hdl.handle.net/20.500.14352/117900 1999-4915 https://doi.org/10.3390/v16111749 39599863 https://www.mdpi.com/1999-4915/16/11/1749 https://pubmed.ncbi.nlm.nih.gov/39599863/ Background: To describe hospitalizations due to respiratory syncytial virus (RSV) infection among children and elderly patients with asthma. Methods: We used a nationwide discharge database to select patients with asthma aged 0 to 15 years and >= 65 years admitted to Spanish hospitals from 2016 to 2022. Results: We identified 49,086 children and 471,947 elderly patients hospitalized with asthma (3.52% and 0.51%, respectively, with RSV). The proportion of RSV increased over time in children with asthma (from 1.44% to 7.4%, p < 0.001) and in elderly individuals (from 0.17% to 1.01%, p < 0.001). Among children with RSV infection, the presence of influenza (OR 3.65; 95% CI 1.46-9.1) and pneumonia (OR 1.85; 95% CI 1.02-3.55) increased the risk of poor outcome. The presence of RSV was associated with severity in these patients, defined by use of mechanical ventilation and/or admission to the intensive care unit (OR 1.44; 95% CI 1.11-1.86). In elderly patients with RSV infection, older age, congestive heart failure, COVID-19, and pneumonia increased the risk of in-hospital mortality (IHM). However, RSV infection was not associated with IHM (OR 0.88; 95% CI 0.68-1.15) in these patients. Conclusion: Our results highlight the impact of RSV infection in children and elderly patients hospitalized with asthma. Strategies to improve surveillance, prophylaxis, and management of RSV infection should be evaluated. eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Burden of Respiratory Syncytial Virus Infection in Children and Older Patients Hospitalized with Asthma: A Seven-Year Longitudinal Population-Based Study in Spain journal article