2026-06-01T01:26:30Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1189632025-03-27T01:10:30Zcom_20.500.14352_14col_20.500.14352_15

Predictive Models of Life Span in Old Female Mice Based on Immune, Redox, and Behavioral Parameters Félix Escalera, Judith Martínez De Toda Cabeza, Irene Díaz Del Cerro, Estefanía Sánchez Del Pozo, Iris Fuente Del Rey, María Mónica De La 591.1 591.5 57.087.1 636.9.02 Aging Life span Immune system Oxidative stress Behavior Mathematical models Fisiología animal (Biología) Comportamiento animal Animales de laboratorio Animales de laboratorio 2401.13 Fisiología Animal 2401.02 Comportamiento Animal 2401.05 desarrollo Animal 2404 Biomatemáticas This research was funded by the Research Group UCM (910379). The development of mathematical models capable of predicting the lifespan of animals is growing. However, there are no studies that compare the predictive power of different sets of parameters depending on the age of the animals. The aim of the present study is to test whether mathematical models for life span prediction developed in adult female mice based on immune, redox, and behavioral parameters can predict life span in old animals and to develop new models in old mice. For this purpose, 29 variables, including parameters of immune function, redox state, and behavioral ones, were evaluated in old female Swiss mice (80 ± 4 weeks). Life span was registered when they died naturally. Firstly, we observed that the models developed in adults were not able to accurately predict the life span of old mice. Therefore, the immunity (adjusted R2 = 73.6%), redox (adjusted R2 = 46.5%), immunity-redox (adjusted R2 = 96.4%), and behavioral (adjusted R2 = 67.9%) models were developed in old age. Finally, the models were validated in another batch of mice. The developed models in old mice show certain similarities to those in adults but include different immune, redox, and behavioral markers, which highlights the importance of age in the prediction of life span. Universidad Complutense de Madrid Depto. de Genética, Fisiología y Microbiología Fac. de Ciencias Biológicas TRUE pub 2025-03-26T09:17:38Z 2025-03-26T09:17:38Z 2024-04-10 journal article VoR https://hdl.handle.net/20.500.14352/118963 1661-6596 10.3390/ijms25084203 1422-0067 eng Félix, J., Martínez de Toda, I., Díaz-Del Cerro, E., Sánchez-Del Pozo, I., & De la Fuente, M. (2024). Predictive Models of Life Span in Old Female Mice Based on Immune, Redox, and Behavioral Parameters. International Journal of Molecular Sciences, 25(8), 4203. https://doi.org/10.3390/ijms25084203 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access application/pdf MDPI