2026-06-28T20:23:06Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1190572025-03-31T23:55:21Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Jimeno, Blanca author Gallego Rubalcaba, Juan Vicente 2025-03-31T12:01:22Z 2025-03-31T12:01:22Z 2024 Jimeno Blanca and Rubalcaba Juan G. 2024Modelling the role of glucocorticoid receptor as mediator of endocrine responses to environmental challengePhil. Trans. R. Soc. B37920220501 http://doi.org/10.1098/rstb.2022.0501 0962-8436 10.1098/rstb.2022.0501 https://hdl.handle.net/20.500.14352/119057 1471-2970 https://doi.org/10.1098/rstb.2022.0501 https://royalsocietypublishing.org/doi/10.1098/rstb.2022.0501 Glucocorticoid hormones (GCs) modulate acute ‘stress’ responses in vertebrates, exerting their actions across many physiological systems to help the organism face and overcome challenges. These actions take place via binding to the glucocorticoid receptor (GR), which determines not only the magnitude of the GC-mediated physiological response but also the negative feedback that downregulates GCs to restore homeostasis. Although GR function is assumed to determine GC regulation capacity, the associations between GR abundance and individuals' coping abilities remain cryptic. We developed a dynamic model fitted to empirical data to predict the effects of GR abundance on both plasma GC response patterns and the magnitude of GC-mediated physiological response. Individuals with higher GRs showed lower GC exposure, stronger physiological responses and greater capacity to adjust this response according to stressor intensity, which may be translated into more resilient and flexible GC phenotypes. Our results also show that among-individual variability in GR abundance challenges the detectability of the association between plasma GC measurements and physiological responses. Our approach provides mechanistic insights into the role of GRs in plasma GC measurements and function, which point at GR abundance fundamentally driving complex features of the GC regulation system in the face of environmental change. eng Attribution 4.0 International Modelling the role of glucocorticoid receptor as mediator of endocrine responses to environmental challenge journal article 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URL https://docta.ucm.es/bitstreams/ec9715d8-2aa0-46ef-a3c7-9514a85091c0/download File MD5 59e6c661e05bf8c427c824fd700662a3 5738241 application/pdf Modelling_role_glucocorticoid.pdf