2026-08-22T00:38:49Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1191592025-04-03T00:05:03Zcom_20.500.14352_14col_20.500.14352_15

Oxidative Score and Microvesicle Profile Suggest Cardiovascular Risk in Chronic Kidney Disease Valera Arévalo, Gemma Rodríguez San Pedro, María del Mar Caro, Paula Jara Cabanillas, Víctor Ortiz Diaz, María Gabriela Figuer, Andrea Yuste, Claudia Ramírez, Rafael Alique, Matilde Morales Ruiz, Enrique Guerra Pérez, Natalia Carracedo Añón, Julia María Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular disease (CVD) due to the accumulation of uremic toxins, altered redox state, and chronic systemic inflammation. This study aimed to analyze the relationship between the redox status of patients with CKD and the phenotype of microvesicles (MVs) subtypes, and cardiovascular events. The oxidative stress level of each participant was determined using an individualized OXY-SCORE. The relationship between pro-oxidant and antioxidant parameters and the expression of membrane markers in endothelial-derived microvesicles (EMVs) and platelet-derived microvesicles (PMVs) was established. Patients with advanced CKD (ACKD) and hemodialysis (HD) had a higher OXY-SCORE than healthy subjects (HS), whereas peritoneal dialysis (PD) patients had similar scores to HS. PD patients showed elevated PMVs and CD41 expression, whereas HD patients had higher EMVs and CD31 expression. Patients with ACKD had higher tissue factor (TF) expression in the PMVs and EMVs. TF expression was correlated with xanthine oxidase (XO) activity and was negatively correlated with antioxidant parameters. Patients with cardiovascular events show elevated TF. In conclusion, microvesicles and oxidative stress may serve as markers of cardiovascular risk in CKD, with TF expression in PMVs and EMVs being potential predictive and prognostic biomarkers of CVD. 2025-04-02T10:35:41Z 2025-04-02T10:35:41Z 2025-04-02T10:35:41Z 2025 journal article https://hdl.handle.net/20.500.14352/119159 2076-3921 10.3390/antiox14020178 eng info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01029/ES/ENVEJECIMIENTO PREMATURO EN PACIENTES CON ENFERMEDAD RENAL CRONICA AVANZADA: UN MODELO PARA ESTABLECER BIOMARCADORES DEL RIESGO CARDIOVASCULAR/ info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F01321/ES/PREDICCION DE LA ENFERMEDAD RENAL: CALCULO DE RIESGO BASADO EN EL ESTADO OXIDATIVO E INFLAMATORIO ASOCIADOS AL ENVEJECIMIENTO/ info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2024 (ISCIII)/PI23%2F01109/ES info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F00240/ES/VESICULAS EXTRACELULARES COMO BIOMARCADORES PRONOSTICOS DE LA ENFERMEDAD CARDIOVASCULAR ASOCIADA A ENFERMEDAD RENAL CRONICA/ info:eu-repo/grantAgreementUAH/Ayuda de la Línea de Actuación Excelencia para el Profesorado Universitario de la UAH/EPU-INV-UAH%2F2022%2F001/ES/ Valera-Arévalo, G., Rodríguez-San Pedro, M. d. M., Caro, P. J., Cabanillas, V., Ortiz-Diaz, M. G., Figuer, A., Yuste, C., Ramírez, R., Alique, M., Morales, E., Guerra-Pérez, N., & Carracedo, J. (2025). Oxidative Score and Microvesicle Profile Suggest Cardiovascular Risk in Chronic Kidney Disease. Antioxidants, 14(2), 178. https://doi.org/10.3390/antiox14020178 http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International MDPI