2026-06-07T17:26:18Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1195312025-04-22T23:47:38Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Xydaki, Flora
author
Arribas Pardo, Paula
author
Burgos Blasco, Bárbara
author
García Feijoo, Julián
author
Méndez Hernández, Carmen Dora
2025-04-22T07:32:34Z
2025-04-22T07:32:34Z
2023-11-08
Xydaki, F., Arribas-Pardo, P., Burgos-Blasco, B., Garcia-Feijoo, J., & Mendez-Hernandez, C. (2023). Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects. Journal of Clinical Medicine, 12(22), 6982. https://doi.org/10.3390/jcm12226982
2077-0383
10.3390/jcm12226982
https://hdl.handle.net/20.500.14352/119531
https://doi.org/10.3390/jcm12226982
https://www.mdpi.com/2077-0383/12/22/6982
Purpose: The aim of this study concerns the evaluation of peripapillary vessel indices in childhood glaucoma (CG) and healthy subjects. Material and Methods: In this prospective, unicenter, observational cross-sectional study, patients with CG and age and sex-matched healthy subjects were included. We compared retinal nerve fiber layer (RNFL) measurements in optical coherence tomography (OCT), peripapillary vessel density (PVD), and the flux index (FI) of the superficial vascular plexus from OCT angiography (OCT-A) between CG patients and control groups. Results: We included 39 patients (68 eyes) with CG and 50 (95 eyes) healthy subjects. The peripapillary RNFL thickness, vessel density, and flux index were significantly lower in the CG group than in the control group. The mean PVD of CG patients was 0.52 ± 0.043%, compared with 0.55 ± 0.014%, p < 0.0001 in healthy subjects. The mean FI was 0.32 ± 0.054 versus 0.37 ± 0.028, p < 0.0001, in CG patients and healthy subjects, respectively. PVD and FI in the superior, inferior, and temporal sectors were significantly lower in CG. The peripapillary RNFL thickness showed a higher area under the ROC curve (AUROC) for discriminating healthy and CG eyes and was significantly different than the PVD (0.797, 95%CI 0.726–0.869; p < 0.0001 vs. 0.664, 95%CI 0.574–0.752; p 0.00037), p 0.012.Conclusions: PVD and FI show lower values in CG and correlate with RNFL thickness measurement but have lower diagnostic ability than RNFL thickness measurement. Our results reveal possible differences in the pathogenesis of microvascular compromise in childhood glaucoma patients.
eng
Attribution 4.0 International
Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects
journal article
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Peripapillary Vascular Density.pdf