2026-06-01T02:21:11Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1199992025-05-13T00:02:31Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Escribano Subías, María Pilar author Pérez Granda, María Jesús author Alonso Fernández, Roberto Alfonso author Catalán Alonso, Pilar author Alcalá, Luis author Serra-Rexarch, José Antonio author Osuna, Laura author Fernández, Alejandro author Conti, Aurora author Castellanos, Alberto author Guinea, Jesús author Muñoz García, Patricia Carmen author Bouza Santiago, Emilio author 2022-04-11 Objective. To assess the impact of COVID-19 at nine nursing homes in Madrid, Spain, during the first wave of COVID-19 infection and lockdown period when preventive measures were taken to avoid transmission among residents. Methods. Nine hundred forty-two residents and 846 staff members from nine nursing homes participated in the study (April 18 to June 20, 2020). All participants were tested for SARS-CoV-2 in the nasopharynx by PCR and for IgG antibodies detection. Microbiological status at sampling was defined as active infection (positive PCR ± presence of antibodies), past infection (negative PCR + presence of antibodies), or naïve participants (negative PCR + absence of antibodies). Results. Laboratory results helped classify the residents as having active infection (n=224; 23.8%), past infection (n=462; 49.1%), or being naïve (n=256; 27.1%); staff members were actively infected (n=127; 15.1%), had had a past infection (n=290; 34.2%), or were naïve (n=429; 50.7%). Overall, the percentage of participants with COVID-19 was significantly higher in residents than in staff members (72.8% vs 49.2%; P=0.001). The clinical situation of residents vs staff at sampling was as follows: acute manifestations compatible with COVID-19 (7.3% vs 3.9%; P<0.01) and no manifestations of infection (92.7% vs 96.0%; P<0.01). A large proportion of both asymptomatic and symptomatic residents (69.4% vs 86.6%; P=0.015) had positive PCR results (mostly alongside positive IgG determinations). Conclusions. COVID-19 affects 75% of the residents in nursing homes in Madrid. The high impact in these settings, despite the strict restrictions adopted during the lockdown, demonstrates the ability of SARS-CoV-2 to cause outbreaks. Escribano P, Pérez-Granda MJ, Alonso R, Catalán P, Alcalá L, Serra-Rexarch JA, et al. High incidence of COVID-19 at nursing homes in Madrid, Spain, despite preventive measures. Revista Espanola de Quimioterapia. 2022;35(3):288-92. 0214-3429 1988-9518 10.37201/req/008.2022 https://hdl.handle.net/20.500.14352/119999 https://doi.org/10.37201/REQ/008.2022 https://seq.es/abstract/rev-esp-quimioter-2022-april-11-2/ High incidence of COVID-19 at nursing homes in Madrid, Spain, despite preventive measures