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From Proof-of-Concept Material to PEGylated and Modularly Targeted Ultrasound-Responsive Mesoporous Silica Nanoparticles Paris, J. L. Villaverde Cantizano, Gonzalo Cabañas Criado, María Victoria Manzano García, Miguel Vallet Regí, María Dulce Nombre 66 546 615.46 Materiales Química inorgánica (Farmacia) 3312 Tecnología de Materiales RESEARCHER ID D-9318-2017 (Juan Luis Paris de la Fuente) ORCID 0000-0001-8950-283X (Juan Luis Paris de la Fuente) RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado) ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado) RESEARCHER ID K-3719-2014 (Miguel Manzano García) ORCID 0000-0001-6238-6111 (Miguel Manzano García) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) In this work we present the synthesis, characterization and in vitro biological evaluation of PEGylated and actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles. This work covers the development of the chemical strategies necessary to afford a modular nanocarrier starting from a proof-of-concept material presented in previous work. This functional ultrasound-responsive material can be adapted to different specific pathological conditions by carefully choosing the appropriate targeting moieties. The new ultrasound responsive material is able to target HeLa cells when conjugated with biotin or an RGD peptide. Ultrasound-responsive cytotoxicity towards cancer cells of doxorubicinloaded nanoparticles is demonstrated in an in vitro cytotoxicity assay. Unión Europea Ministerio de Economía, Comercio y Empresa (España) Depto. de Química en Ciencias Farmacéuticas Fac. de Farmacia TRUE pub 2023-06-17T12:26:38Z 2023-06-17T12:26:38Z 2018-04-11 journal article https://hdl.handle.net/20.500.14352/12028 2050-750X 10.1039/C8TB00444G eng VERDI (694160) MAT2015- 64831-R info:eu-repo/grantAgreement/EC/H2020/Number of agreement Paris, J. L., Villaverde Cantizano, G., Cabañas Criado, M. V. et al. «From Proof-of-Concept Material to PEGylated and Modularly Targeted Ultrasound-Responsive Mesoporous Silica Nanoparticles». Journal of Materials Chemistry B, vol. 6, n.o 18, 2018, pp. 2785-94. DOI.org (Crossref), https://doi.org/10.1039/C8TB00444G. open access application/pdf Royal Society of Chemistry