2026-06-29T15:17:23Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/120662024-04-16T17:57:33Zcom_20.500.14352_14col_20.500.14352_15
Nanotechnological Strategies for Protein Delivery
Villegas Díaz, María Rocío
Baeza, Alejandro
Vallet Regí, María Dulce Nombre
66
546
615.46
Protein delivery system
PEGylation
Liposomes
Nanoparticles
Polymeric nanocapsules
Vprotein therapy
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
RESEARCHER ID V-7077-2017 (María Rocío Villegas Díaz)
ORCID 0000-0002-1297-2355 (María Rocío Villegas Díaz)
RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-2026-6266 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target. Moreover, several proteins are unable to cross the cell membrane. All these facts strongly hinder their therapeutic effect. Nanomedicine has emerged as a powerful tool which can provide solutions to solve these limitations and improve the efficacy of treatments based on protein administration. This review discusses the advantages and limitations of different types of strategies employed for protein delivery, such as PEGylation, transport within liposomes or inorganic nanoparticles or their in situ encapsulation.
Unión Europea. H2020
Ministerio de Economía y Competitividad (MINECO)
Depto. de Química en Ciencias Farmacéuticas
Fac. de Farmacia
TRUE
pub
2023-06-17T12:27:00Z
2023-06-17T12:27:00Z
2018-04-25
journal article
https://hdl.handle.net/20.500.14352/12066
1420-3049
10.3390/molecules23051008
eng
VERDI (694160)
MAT2015-64831-R
open access
application/pdf
MDPI