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Utility of Bruch membrane opening-based optic nerve head parameters in myopic subjects Sastre Ibáñez, Marina Martínez De La Casa Fernández-Borrella, José María Rebolleda Fernández, Gema Cifuentes Canorea, Pilar Moreno, María Nieves Morales Fernández, Laura Sáenz Francés, Federico García Feijoo, Julián 617.731-073.75 617.753.2 Bruch membrane opening Myopia Optic nerve head Optical coherence tomography Retinal nerve fiber layer Diagnóstico por imagen y medicina nuclear Oftalmología Optometría Técnicas de la imagen 3204.01 Medicina Nuclear 3201.09 Oftalmología 2209.15 Optometría Purpose: To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia. Methods: In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software. With GPME, we analyzed the neuroretinal rim (Bruch membrane opening-minimum rim width [BMO-MRW]) and RNFL. Results: The average age of subjects was 30.2 ± 9.3 years for G0 and 29.9 ± 7.1 years for G1 (p = 0.903). Mean sphere was −0.5 ± 0.3 D (-1.25 to 0 D) G0 and -3.9 ± 0.3 D (-6.00 to -3 D) G1 (p<0.001). The RNFL thickness comparison between G0 and G1 showed a significantly lower thickness in G1 (p = 0.018). The BMO-MRW measurements were similar in both groups (p = 0.331). With the BMO-MRW examination, the number of sectors classified as pathologic per subject in G1 were significantly lower compared to RNFL analysis (p = 0.023). Conclusions: Ring analysis based on BMO-MRW measurements shows a lower rate of false-positives compared to RNFL thickness when studying healthy moderate myopic eyes and it would be advisable to take this into consideration when analyzing these patients. Instituto de Salud Carlos III Redes Temáticas de Investigación Cooperativa en Salud (España) OFTARED Universidad Complutense de Madrid Unidad Docente de Inmunología, Oftalmología y ORL Fac. de Óptica y Optometría TRUE pub Article first published online: November 8, 2017; Issue published: January 1, 2018 Received: July 09, 2017; Accepted: August 11, 2017 2023-06-17T12:27:04Z 2023-06-17T12:27:04Z 2018-01-01 journal article https://hdl.handle.net/20.500.14352/12072 1120-6721 10.5301/ejo.5001022 eng 920415-GR58/0 Sastre Ibáñez, M., Martínez De La Casa Fernández-Borrella, J. M., Rebolleda Fernández, G. et al. «Utility of Bruch Membrane Opening-Based Optic Nerve Head Parameters in Myopic Subjects». European Journal of Ophthalmology, vol. 28, n.o 1, enero de 2018, pp. 42-46. DOI.org (Crossref), https://doi.org/10.5301/ejo.5001022. restricted access application/pdf Sage Publications