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oai:docta.ucm.es:20.500.14352/121372023-08-10T22:15:20Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Crespo Castrillo, Andrea author Yanguas Casás, Natalia author Arévalo, María Ángeles author Azcoitia Elías, Iñigo author Barreto, George E. author García Segura, Luis Miguel 2023-06-17T12:27:44Z 2023-06-17T12:27:44Z 2018-03-26 0893-7648, ESSN: 1559-1182 10.1007/s12035-018-1008-x https://hdl.handle.net/20.500.14352/12137 https://link.springer.com/article/10.1007/s12035-018-1008-x Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actions regulate reactive gliosis. Tibolone is a synthetic steroid that is widely used for the treatment of climacteric symptoms and/or the prevention of osteoporosis. In this study, we have assessed the effect of tibolone on reactive gliosis in the cerebral cortex after a stab wound brain injury in ovariectomized adult female mice. By 7 days after brain injury, tibolone reduced the number of glial fibrillary acidic protein (GFAP) immunoreactive astrocytes, the number of ionized calcium binding adaptor molecule 1 (Iba1) immunoreactive microglia, and the number of microglial cells with a reactive phenotype in comparison to vehicle-injected animals. These effects on gliosis were associated with a reduction in neuronal loss in the proximity to the wound, suggesting that tibolone exerts beneficial homeostatic actions in the cerebral cortex after an acute brain injury. eng The synthetic steroid tibolone decreases reactive gliosis and neuronal death in the cerebral cortex of female mice after a stab wound injury journal article URL https://docta.ucm.es/bitstreams/47d7c99c-b209-4010-a4e1-66b78fc3453f/download File MD5 8cca33230a5b71dfba09ce52fe75123f 10338470 application/pdf Crespo Castrillo, A. et al. 2018. The synthetic steroid tibolone.pdf URL https://docta.ucm.es/bitstreams/19fb6295-a9a0-478e-a25d-704fe3db5002/download File MD5 e0a5ced9a7df1397b1c039cfe1602ae5 78967 text/plain Crespo Castrillo, A. et al. 2018. The synthetic steroid tibolone.pdf.txt