2026-06-07T16:54:04Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1215082025-06-18T23:51:19Zcom_20.500.14352_14col_20.500.14352_15
Neuroestradiol and neuronal development: not an exclusive male tale anymore
García Segura, Luis M.
Méndez, Pablo
Arévalo, M. Angeles
Azcoitia Elías, Íñigo
The brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain development. In addition, recent findings have shown sex-specific actions of neuroestradiol on neuroblast migration, neuritic growth and synaptogenesis in females. Among other factors, the epigenetic regulation exerted by X linked genes, such as Kdm6a/Utx, may determine sex-specific actions of neuroestradiol in the female brain. This review evidences the impact of neuroestradiol on brain formation in both sexes and highlights the interaction of neural steriodogenesis, hormones and sex chromosomes in sex-specific brain development.
2025-06-18T15:56:03Z
2025-06-18T15:56:03Z
2025-06-18T15:56:03Z
2023-09
journal article
https://hdl.handle.net/20.500.14352/121508
0091-3022
10.1016/j.yfrne.2023.101102
eng
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115019RB-I00/ES/IMPACTO DEL SEXO Y LA EDAD SOBRE LA FUNCION DE LA GLIA EN EL CEREBRO LESIONADO /
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112824GB-I00/ES/SINTESIS LOCAL DE ESTROGENOS EN NEURONAS INHIBITORIAS DEL HIPOCAMPO: IMPLICACIONES PARA LA FUNCION CEREBRAL Y EFECTOS DEL SEXO/
García-Segura LM, Méndez P, Arevalo MA, Azcoitia I. Neuroestradiol and neuronal development: Not an exclusive male tale anymore. Frontiers in Neuroendocrinology 2023;71:101102. https://doi.org/10.1016/j.yfrne.2023.101102.
http://creativecommons.org/licenses/by/4.0/
open access
Attribution 4.0 International
Elsevier