2026-06-28T20:21:01Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1228442025-07-29T23:54:30Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Ramírez López, Pedro author Jorge Losada Méndez author Francisca Palomares author Francisca Gómez author Javier Ramos-Soriano author Maria Jose Torres author Cristobalina Mayorga author Javier Rojo author 2021 Covalent conjugation of allergens to toll-like receptor (TLR) agonists appears to be a powerful strategy for the development of safety compounds for allergen-specific immunomodulatory response toward tolerance in allergy. In this work, we have synthesized two family of ligands, an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-b]indole as a ligand for TLR4, both conjugated with a T-cell peptide of Pru p 3 allergen, the lipid transfer protein (LTP) responsible for LTP-dependent food allergy. These conjugates interact with dendritic cells, inducing their specific maturation, T-cell proliferation, and cytokine production in peach allergic patients. Moreover, they increased the Treg-cell frequencies in these patients and could induce the IL-10 production. These outcomes were remarkable in the case of the TLR7 ligand conjugated with Pru p 3, opening the door for the potential application of these allergen–adjuvant systems in food allergy immunotherapy. Jorge Losada Méndez, Francisca Palomares, Francisca Gómez, Pedro Ramírez-López, Javier Ramos-Soriano, Maria Jose Torres, Cristobalina Mayorga, and Javier Rojo ACS Chemical Biology 2021 16 (11), 2651-2664 10.1021/acschembio.1c00765 https://hdl.handle.net/20.500.14352/122844 https://doi.org/10.1021/acschembio.1c00765 Immunomodulatory Response of Toll-like Receptor Ligand−Peptide Conjugates in Food Allergy